Caloric restriction mimetic 2-deoxyglucose alleviated lethal liver injury induced by lipopolysaccharide/D-galactosamine in mice

被引：7

作者：

Che, Qian ^{[1
]}

Lin, Ling ^{[1
]}

Ai, Qing ^{[2
]}

Ge, Pu ^{[1
]}

Dai, Jie ^{[3
]}

Jiang, Rong ^{[4
]}

Zhou, Dan ^{[1
]}

Wan, Jingyuan ^{[5
]}

Zhang, Li ^{[1
,4
]}

机构：

[1] Chongqing Med Univ, Dept Pathophysiol, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Dept Physiol, Chongqing 400016, Peoples R China

[3] Hosp Chongqing Univ Arts & Sci, Chongqing, Peoples R China

[4] Chongqing Med Univ, Lab Stem Cell & Tissue Engn, Chongqing 400016, Peoples R China

[5] Chongqing Med Univ, Dept Pharmacol, Chongqing 400016, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 459卷 / 03期

关键词：

Calorie restriction mimetic; 2-Deoxyglucose; Lipopolysaccharide; Liver injury; TNF-ALPHA; DIETARY RESTRICTION; INDUCED APOPTOSIS; GLYCOLYSIS; CELLS; DEATH; 2-DEOXY-D-GLUCOSE; INHIBITION; MECHANISMS; KINASE;

D O I：

10.1016/j.bbrc.2015.02.145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The glycolytic inhibitor 2-deoxyglucose (2-DG) is a calorie restriction (CR) mimetic produces CR-like beneficial effects in both acute and chronic pathological processes, but whether 2-DG is also helpful in critical and life-threatening situation is not known. In the present study, the potential benefits of 2-DG in lipopolysaccharide/D-galactosamine (LPS/D-Gal)-induced lethal liver injury were investigated. The results indicated that treatment with 2-DG suppressed the elevation of plasma aminotransferases, alleviated the histopathological abnormalities and improved the survival rate of LPS/D-Gal-exposed mice. Treatment with 2-DG also suppressed the production of pro-apoptotic cytokine TNF-alpha, the phosphorylation of JNK, the activation of caspase cascade and the count of TUNEL-positive apoptotic hepatocytes. These data suggested that the CR mimetic 2-DG could also provide beneficial effects in lethal pathological process such as LPS/D-Gal-induced fulminant liver injury. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：541 / 546

页数：6

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