A chemoselective aniline-chloropyrimidine coupling in a competing electrophilic environment

被引：27

作者：

Choudhury, Anusuya ^{[1
]}

Chen, Hongfeng ^{[1
]}

Nilsen, Christopher N. ^{[1
]}

Sorgi, Kirk L. ^{[1
]}

机构：

[1] LLC, Johnson & Johnson Pharmaceut Res & Dev, Chem Dev, Raritan, NJ 08869 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 01期

关键词：

Acid catalyzed coupling; Chloropyrimidine; Diaminopyrimidines;

D O I：

10.1016/j.tetlet.2007.11.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly chemoselective substitution on 4-amino-6-chloropyrimidine ring system having a competing aldehyde functionality has been realized with anilines which produces 4, 6-diaminopyrimidine-5-carbaldehyde in high yield. The reaction may involve the intermediacy of imines. A variety of aromatic amines participate in this reaction successfully to generate diaminopyrimidine aldehydes in moderate to high yield. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：102 / 105

页数：4

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