neo-Clerodane Diterpenoids from the Aerial Part of Scutellaria barbata

被引：14

作者：

Lee, Hanna ^{[1
]}

Shim, Sang Hee ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, Gyeongbuk, South Korea

来源：

HELVETICA CHIMICA ACTA | 2011年 / 94卷 / 04期

关键词：

CYTOTOXIC ACTIVITIES; ALKALOIDS; CANCER;

D O I：

10.1002/hlca.201000271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new neo-clerodane diterpenoids, barbatellarines C-E (1-3), were isolated from the CHCl(3)-soluble fraction of the aerial part of Scutellaria barbata. Their chemical structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 were C(13) epimers, which was confirmed by an NOE difference experiment and the NOESY spectrum. The relative configuration was determined on the basis of the (1)H-NMR J-value and NOE data, while the absolute configuration of the previously isolated analogue, barbatellarine B (4), as a representative member of the group, was assigned by CD analysis.

引用

页码：643 / 649

页数：7

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