The Importance of Dielectric Constant for Drug Solubility Prediction in Binary Solvent Mixtures: Electrolytes and Zwitterions in Water plus Ethanol

被引：34

作者：

Fakhree, Mohammad Amin Abolghassemi ^{[1
]}

Delgado, Daniel R. ^{[2
]}

Martinez, Fleming ^{[2
]}

Jouyban, Abolghasem ^{[3
,4
]}

机构：

[1] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz 51664, Iran

[2] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farm Fis Quim, Bogota 14490, DC, Colombia

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

来源：

AAPS PHARMSCITECH | 2010年 / 11卷 / 04期

关键词：

dielectric constant; electrolyte; solubility prediction; water plus ethanol; zwitterions; MODEL;

D O I：

10.1208/s12249-010-9552-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Improving solubility prediction methods or making them easy to use is highly demanded in the pharmaceutical industries. It can be used in formulation design and pharmaceutically related processes such as crystallization. In this work, we have showed that dielectric constants of solvents and their mixtures might be helpful in solubility prediction of electrolytes and zwitterions with acceptable error in water+ ethanol mixtures. © 2010 American Association of Pharmaceutical Scientists.

引用

页码：1726 / 1729

页数：4

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