The mechanism of propofol in cancer development: An updated review

被引：46

作者：

Gao, Xingchun ^{[1
,2
,3
]}

Mi, Yajing ^{[1
,2
,3
]}

Guo, Na ^{[1
,2
]}

Luan, Jing ^{[1
,2
,3
]}

Xu, Hao ^{[1
,2
,3
]}

Hu, Zhifang ^{[1
,2
]}

Wang, Ning ^{[1
,2
]}

Zhang, Dian ^{[1
,2
]}

Gou, Xingchun ^{[1
,2
]}

Xu, Lixian ^{[1
,2
,3
]}

机构：

[1] Xian Med Univ, Inst Basic Med Sci, Xian 710021, Peoples R China

[2] Xian Med Univ, Shaanxi Key Lab Ischem Cardiovasc Dis, Shaanxi Key Lab Brain Disorders, Xian, Peoples R China

[3] Fourth Mil Med Univ, Sch Stomatol, Dept Anesthesiol, State Key Lab Mil Stomatol, Xian 710032, Peoples R China

来源：

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY | 2020年 / 16卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cancer; epigenetic pathways; immune function; molecular mechanism; propofol; NF-KAPPA-B; NATURAL-KILLER-CELL; PANCREATIC-CANCER; INHIBITS INVASION; SUPPRESSES PROLIFERATION; MESENCHYMAL TRANSITION; SIGNALING PATHWAY; DOWN-REGULATION; TUMOR INVASION; GASTRIC-CANCER;

D O I：

10.1111/ajco.13301

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a key cause of death worldwide. Despite the development of radiotherapy, chemotherapy and even immunotherapy, surgery remains the standard treatment for cancer patients. Recently, many studies have shown that propofol, a commonly used anesthetic drug, can affect the prognosis of cancer. In this review, we provide an overview of the molecular mechanisms of propofol in the development of cancer. Propofol not only affects epigenetic pathways, such as those involving miRNA, lncRNA and histone acetylation, but also modulates genetic signaling pathways, including the hypoxia, NF-kappa B, MAPK, SLUG and Nrf2 pathways. In addition, propofol influences the immune function of patients and impacts the degree of immunosuppression. Furthermore, we briefly summarize the clinical trials on the effect of propofol in cancer development. Ultimately, further studies distinguishing the types of tumors in clinical trials are needed to clarify the correlation between propofol and cancer.

引用

页码：E3 / E11

页数：9

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