Understanding DNA replication by the bacteriophage T4 replisome

被引：16

作者：

Benkovic, Stephen J. ^{[1
]}

Spiering, Michelle M. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, Wartik Labs 414, University Pk, PA 16802 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2017年 / 292卷 / 45期

基金：

美国国家卫生研究院;

关键词：

bacteriophage; DNA-binding protein; DNA helicase; DNA polymerase; DNA primase; DNA replication; LAGGING-STRAND SYNTHESIS; POLYMERASE ACCESSORY PROTEINS; COORDINATED LEADING-STRAND; OKAZAKI FRAGMENT SYNTHESIS; SLIDING CLAMP INTERACTIONS; HELICASE LOADER PROTEIN; PRIMER SYNTHESIS; SINGLE-MOLECULE; HOLOENZYME COMPLEX; CRYSTAL-STRUCTURE;

D O I：

10.1074/jbc.R117.811208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.

引用

页码：18434 / 18442

页数：9

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