Understanding DNA replication by the bacteriophage T4 replisome

被引：16

作者：

Benkovic, Stephen J. ^{[1
]}

Spiering, Michelle M. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, Wartik Labs 414, University Pk, PA 16802 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2017年 / 292卷 / 45期

基金：

美国国家卫生研究院;

关键词：

bacteriophage; DNA-binding protein; DNA helicase; DNA polymerase; DNA primase; DNA replication; LAGGING-STRAND SYNTHESIS; POLYMERASE ACCESSORY PROTEINS; COORDINATED LEADING-STRAND; OKAZAKI FRAGMENT SYNTHESIS; SLIDING CLAMP INTERACTIONS; HELICASE LOADER PROTEIN; PRIMER SYNTHESIS; SINGLE-MOLECULE; HOLOENZYME COMPLEX; CRYSTAL-STRUCTURE;

D O I：

10.1074/jbc.R117.811208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.

引用

页码：18434 / 18442

页数：9

共 50 条

[1] Coordinated DNA Replication by the Bacteriophage T4 Replisome
Noble, Erin
Spiering, Michelle M.
Benkovic, Stephen J.
VIRUSES-BASEL, 2015, 7 (06): : 3186 - 3200
[2] On DNA replication by the T4 replisome
Benkovic, SJ
FASEB JOURNAL, 2005, 19 (04): : A810 - A810
[3] DNA replication by the T4 replisome.
Benkovic, SJ
Valentine, AM
Yang, JS
Roccasecca, RM
Trakselis, M
Jun, X
BIOCHEMISTRY, 2003, 42 (28) : 8651 - 8651
[4] On DNA replication by the T4 replisome.
Benkovic, SJ
Valentine, AM
Yang, JS
Roccasecca, RM
Trakselis, M
Jun, X
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U192 - U192
[5] On DNA replication by the T4 replisome.
Benkovic, S
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U135 - U135
[6] On DNA replication by the T4 replisome.
Benkovic, SJ
BIOCHEMISTRY, 2001, 40 (29) : 8634 - 8634
[7] On DNA replication by the T4 replisome.
Benkovic, S
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U239 - U239
[8] DNA replication of bacteriophage T4 in vivo
Mosig, G
Colowick, N
DNA REPLICATION, 1995, 262 : 587 - 604
[9] Repetitive lagging strand DNA synthesis by the bacteriophage T4 replisome
Spiering, Michelle M.
Nelson, Scott W.
Benkovic, Stephen J.
MOLECULAR BIOSYSTEMS, 2008, 4 (11) : 1070 - 1074
[10] Purification of bacteriophage T4 DNA replication proteins
Nossal, NG
Hinton, DM
Hobbs, LJ
Spacciapoli, P
DNA REPLICATION, 1995, 262 : 560 - 584

← 1 2 3 4 5 →