Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids

被引：89

作者：

Kramer, Susanne ^{[1
]}

Carrington, Mark ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

来源：

TRENDS IN PARASITOLOGY | 2011年 / 27卷 / 01期

基金：

英国惠康基金;

关键词：

CELL-CYCLE REGULATION; SEQUENCE BINDING-PROTEIN; SPLICED LEADER RNA; CRITHIDIA-FASCICULATA; GENE-EXPRESSION; CCCH PROTEIN; DEVELOPMENTAL REGULATION; 3'-UNTRANSLATED REGION; POLYPYRIMIDINE TRACT; DOMAIN PROTEINS;

D O I：

10.1016/j.pt.2010.06.011

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In trypanosomatids, alterations in gene expression in response to intrinsic or extrinsic signals are achieved through post-transcriptional mechanisms. In the last 20 years, research has concentrated on defining the responsible cis-elements in the untranslated regions of several regulated mRNAs. More recently, the focus has shifted towards the identification of RNA-binding proteins that act as trans-acting factors. Trypanosomatids have a large number of predicted RNA-binding proteins of which the vast majority have no orthologues in other eukaryotes. Several RNA-binding proteins have been shown to bind and/or regulate the expression of a group of mRNAs that code for functionally related proteins, indicating the possible presence of co-regulated mRNA cohorts.

引用

页码：23 / 30

页数：8

共 78 条

[1] Trypanosoma brucei PUF9 Regulates mRNAs for Proteins Involved in Replicative Processes over the Cell Cycle [J].

Archer, Stuart K. ;

Luu, Van-Duc ;

de Queiroz, Rafael A. ;

Brems, Stefanie ;

Clayton, Christine .

PLOS PATHOGENS, 2009, 5 (08)

[2] Sequence elements in both the intergenic space and the 3′ untranslated region of the Crithidia fasciculata KAP3 gene are required for cell cycle regulation of KAP2 mRNA [J].

Avliyakulov, NK ;

Hines, JC ;

Ray, DS .

EUKARYOTIC CELL, 2003, 2 (04) :671-677

[3] TIS11 Family Proteins and Their Roles in Posttranscriptional Gene Regulation [J].

Baou, Maria ;

Jewell, Andrew ;

Murphy, John J. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2009,

[4] The FIP-1 like polyadenylation factor in trypanosomes and the structural basis for its interaction with CPSF30 [J].

Bercovich, Natalia ;

Levin, Mariano J. ;

Vazquez, Martin P. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 380 (04) :850-855

[5] The galvanization of biology: A growing appreciation for the roles of zinc [J].

Berg, JM ;

Shi, YG .

SCIENCE, 1996, 271 (5252) :1081-1085

[6] MRNA cycling sequence binding protein from Leishmania donovani (LdCSBP) is covalently modified by ubiquitination [J].

Bhandari, Dipankar ;

Saha, Partha .

FEMS MICROBIOLOGY LETTERS, 2007, 273 (02) :206-213

[7] The transcriptomes of Trypanosoma brucei Lister 427 and TREU927 bloodstream and procyclic trypomastigotes [J].

Brems, S ;

Guilbride, DL ;

Gundlesdodjir-Planck, D ;

Busold, C ;

Luu, VD ;

Schanne, M ;

Hoheisel, J ;

Clayton, C .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2005, 139 (02) :163-172

[8] Cell cycle regulation of RPA1 transcript levels in the trypanosomatid Crithidia fasciculata [J].

Brown, LM ;

Ray, DS .

NUCLEIC ACIDS RESEARCH, 1997, 25 (16) :3281-3289

[9] Protein interactions within the TcZFP zinc finger family members of Trypanosoma cruzi:: Implications for their functions [J].

Caro, F ;

Bercovich, N ;

Atorrasagasti, C ;

Levin, MJ ;

Vázquez, MP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 333 (03) :1017-1025

[10] Trypanosoma cruzi:: Analysis of the complete PUF RNA-binding protein family [J].

Caro, Florence ;

Bercovich, Natalia ;

Atorrasagasti, Catalina ;

Levin, Mariano J. ;

Vazquez, Martin P. .

EXPERIMENTAL PARASITOLOGY, 2006, 113 (02) :112-124

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