Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium

被引：30

作者：

Shimano, Kristin A. ^{[1
]}

Narla, Anupama ^{[2
]}

Rose, Melissa J. ^{[3
]}

Gloude, Nicholas J. ^{[4
]}

Allen, Steven W. ^{[5
]}

Bergstrom, Katie ^{[6
]}

Broglie, Larisa ^{[7
]}

Carella, Beth A. ^{[8
]}

Castillo, Paul ^{[9
]}

de Jong, Jill L. O. ^{[10
]}

Dror, Yigal ^{[11
]}

Geddis, Amy E. ^{[6
]}

Huang, James N. ^{[1
]}

Lau, Bonnie W. ^{[12
]}

McGuinn, Catherine ^{[13
]}

Nakano, Taizo A. ^{[14
]}

Overholt, Kathleen ^{[15
]}

Rothman, Jennifer A. ^{[16
]}

Sharathkumar, Anjali ^{[17
]}

Shereck, Evan ^{[18
]}

Vlachos, Adrianna ^{[19
]}

Olson, Timothy S. ^{[20
,21
]}

Bertuch, Alison A. ^{[22
]}

Wlodarski, Marcin W. ^{[23
]}

Shimamura, Akiko ^{[24
,25
]}

Boklan, Jessica ^{[26
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA USA

[2] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[3] Ohio State Univ, Coll Med, Nationwide Childrens Hosp, Div Hematol Oncol & Bone Marrow Transplant, Columbus, OH 43210 USA

[4] Univ Calif San Diego, Dept Pediat, Rady Childrens Hosp, San Diego, CA 92103 USA

[5] Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Pediat Hematol Oncol, Sch Med, Pittsburgh, PA USA

[6] Seattle Childrens Hosp, Canc & Blood Disorders Ctr, Washington, DC USA

[7] Med Coll Wisconsin, Dept Pediat Hematol Oncol Blood & Marrow Transpla, Milwaukee, WI 53226 USA

[8] Kaiser Permanente, Dept Pediat, Washington, DC USA

[9] UF Hlth Shands Childrens Hosp, Div Pediat Hematol Oncol, Gainesville, FL USA

[10] Univ Chicago, Dept Pediat, Sect Hematol Oncol, Chicago, IL 60637 USA

[11] Hosp Sick Children, Dept Paediat, Marrow Failure & Myelodysplasia Program, Div Hematol & Oncol, Toronto, ON, Canada

[12] Dartmouth Hitchcock, Pediat Hematol Oncol, Lebanon, NH USA

[13] Weill Cornell Med, Dept Pediat, New York, NY USA

[14] Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO USA

[15] Indiana Univ, Riley Hosp Children, Pediat Hematol & Oncol, Indianapolis, IN 46204 USA

[16] Duke Univ, Med Ctr, Div Pediat Hematol & Oncol, Durham, NC USA

[17] Univ Iowa, Carver Coll Med, Stead Family Dept Pediat, Iowa City, IA USA

[18] Oregon Hlth & Sci Univ, Dept Pediat, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA

[19] Cohen Childrens Med Ctr, Hematol Oncol & Cellular Therapy, New Hyde Pk, NY USA

[20] Childrens Hosp Philadelphia, Dept Pediat, Cell Therapy & Transplant Sect, Div Oncol & Bone Marrow Failure,Div Hematol, Philadelphia, PA 19104 USA

[21] Univ Penn, Philadelphia, PA 19104 USA

[22] Baylor Coll Med, Pediat, Houston, TX 77030 USA

[23] St Jude Childrens Res Hosp, Dept Hematol, Memphis, TN USA

[24] Boston Childrens Hosp, Canc & Blood Disorders Ctr, Boston, MA USA

[25] Dana Farber Canc Inst, Boston, MA 02115 USA

[26] Phoenix Childrens Hosp, Ctr Canc & Blood Disorders, Phoenix, AZ 85016 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2021年 / 96卷 / 11期

关键词：

PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; BONE-MARROW-TRANSPLANTATION; SHWACHMAN-DIAMOND-SYNDROME; GPI-DEFICIENT CELLS; TELOMERE LENGTH; FETAL-HEMOGLOBIN; IMMUNOSUPPRESSIVE THERAPY; REFRACTORY CYTOPENIA; FANCONI-ANEMIA; MYELODYSPLASTIC SYNDROMES;

D O I：

10.1002/ajh.26310

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist-oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in North America with interest and expertise in aplastic anemia, inherited bone marrow failure syndromes, and myelodysplastic syndromes. The NAPAAC Bone Marrow Failure Diagnosis and Care Guidelines Working Group was established with the charge of harmonizing the approach to the diagnostic workup of aplastic anemia in an effort to standardize best practices in the field. This document outlines the rationale for initial evaluations in pediatric patients presenting with signs and symptoms concerning for severe aplastic anemia.

引用

页码：1491 / 1504

页数：14

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