Immature platelet fraction: is a novel early predictive marker for disease severity in patients with Covid-19 pneumonia?

被引：5

作者：

Incir, Said ^{[1
]}

Komesli, Zeynep ^{[2
]}

Baygul, Arzu ^{[3
]}

Tasdemir, Zeynep Atam ^{[4
]}

Palaoglu, Kerim Erhan ^{[5
]}

Kant, Hatice ^{[6
]}

Kapmaz, Mahir ^{[7
]}

Tekin, Suda ^{[7
]}

Kilic, Alparslan ^{[8
]}

Dagel, Tuncay ^{[9
]}

Okan, Ayse ^{[6
]}

Somay, Kayra ^{[2
]}

Akpinar, Timur Selcuk ^{[10
]}

机构：

[1] Koc Univ Hosp, Clin Biochem Lab, Davutpasa St 4 Topkapi, TR-34010 Istanbul, Turkey

[2] Koc Univ Hosp, Dept Internal Med, Istanbul, Turkey

[3] Koc Univ, Sch Med, Istanbul, Turkey

[4] Bagcilar Training & Res Hosp, Dept Pulmonol, Istanbul, Turkey

[5] Amer Hosp, Dept Clin Lab, Istanbul, Turkey

[6] Koc Univ Hosp, Dept Clin Lab, Istanbul, Turkey

[7] Koc Univ Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey

[8] Koc Univ Hosp, Dept Cardiol, Istanbul, Turkey

[9] Koc Univ Hosp, Dept Internal Med, Div Nephrol, Istanbul, Turkey

[10] Koc Univ, Dept Internal Med, Sch Med, Istanbul, Turkey

来源：

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI | 2021年 / 46卷 / 04期

关键词：

biomarker; blood cell count; COVID-19; immature platelet fraction; SARS-CoV-2; CLINICAL-RELEVANCE; SEPSIS;

D O I：

10.1515/tjb-2021-0070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objectives: In many diseases, immature platelet fraction (IPF%) is related to coagulopathy and poor outcome. This study aimed to investigate the predictive value of IPF% for the severity of pneumonia in patients with Coronavirus Disease 2019 (COVID-19). Methods: A total of 154 patients with COVID-19 infections were included. The patients were divided into two groups according to the severity of pneumonia (severe and nonsevere) regarding their oxygen demand. Results: Given laboratory parameters, the median IPF% was significantly higher in the severe group (11.9 vs. 3.9%, p<0.001). Mean platelet volume (p<0.001), platelet-large cell ratio (p=0.001), platelet distribution width (p=0.001), D-Dimer (p<0.001), INR (p=0.003), and aPTT (p=0.007) were also found to be significantly higher in the severe group. Moreover, IPF (p=0.014, Odds ratio = 2.000, 95%CI: 1.149-3.482) was an independent predictor for the severity. The curve value from receiver operating characteristics was 0.879 (p<0.001, 95%CI: 0.784-0.943) for determining the severity of pneumonia. IPF% had a sensitivity and specificity value of 69.5 and 92.4% to detect the disease's severity. Conclusions: IPF% is an independent predictor for the severity of COVID-19 pneumonia. Assessment of IPF% may both help to early determine high-risk patients with COVID-19 and to alert the physicians.

引用

页码：359 / 366

页数：8