Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice

被引：6

作者：

Morokata, T ^{[1
]}

Suzuki, K ^{[1
]}

Ida, K ^{[1
]}

Yamada, T ^{[1
]}

机构：

[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Inflammat Res Pharmacol Labs, Tsukuba, Ibaraki 3058585, Japan

来源：

IMMUNOLOGY LETTERS | 2005年 / 98卷 / 01期

关键词：

YM-90709; IL-5; eosinophil; BALF;

D O I：

10.1016/j.imlet.2004.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A newly synthesized compound, YM-90709, 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8,]indolizino[2,3-b]quinoxaline, was previously reported to specifically inhibit the binding of interleukin-5 (IL-5) to its receptor (R) on human eosinophils. In this study, the intravenous injection of YM-90709 inhibited antigen-induced infiltration of eosinophils into the bronchoalveolar lavage fluid (BALF) of BDF1 mice, with an ED50 value of 0.050 mg/kg. Anti-murine IL-5 monoclonal antibody (mAb) also inhibited the infiltration of eosinophils with an ED50 value of 0.035 mg/kg. These results indicate that YM-90709, which is a novel IL-5R antagonist, inhibits antigen-induced eosinophil recruitment into the airway, the same as anti-IL-5 mAb does. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：161 / 165

页数：5

共 15 条

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