Disulfide-containing Macromolecules for Therapeutic Delivery

被引：27
作者：
Jiang, Ziwen [1 ]
Thayumanavan, S. [1 ]
机构：
[1] Univ Massachusetts Amherst, Dept Chem, Inst Appl Life Sci, Mol & Cellular Biol Program,Ctr Bioact Delivery, Amherst, MA 01003 USA
来源：
ISRAEL JOURNAL OF CHEMISTRY | 2020年 / 60卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
Disulfide bond; polymer; stimuli responsive; drug delivery; DRUG-DELIVERY; INTRACELLULAR DELIVERY; POLYMER NANOGELS; PROTEIN; GLUTATHIONE; REDOX; REDUCTION; NANOPARTICLES; SYSTEMS; DESIGN;
D O I：
10.1002/ijch.201900160
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Development of macromolecules provides applicable platforms for the delivery of therapeutics. In this general overview, we focus on the design principles of synthetic polymers, with disulfide bonds located in either the polymer backbone or side chains. We also discuss the role of disulfide bonds, as well as the remaining questions to better understand their applications in therapeutic delivery systems.
引用
收藏
页码：132 / 139
页数：8
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