Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility

被引：136

作者：

Ding, Lijun ^{[1
,2
]}

Yan, Guijun ^{[1
]}

Wang, Bin ^{[1
,2
]}

Xu, Lu ^{[1
]}

Gu, Yan ^{[3
]}

Ru, Tong ^{[3
]}

Cui, Xiaoying ^{[1
]}

Lei, Lei ^{[1
]}

Liu, Jingyu ^{[1
]}

Sheng, Xiaoqiang ^{[1
]}

Wang, Bin ^{[1
,2
]}

Zhang, Chunxue ^{[1
]}

Yang, Yanjun ^{[1
]}

Jiang, Ruiwei ^{[1
]}

Zhou, Jianjun ^{[1
]}

Kong, Na ^{[1
]}

Lu, Feifei ^{[1
]}

Zhou, Huaijun ^{[3
]}

Zhao, Yannan ^{[4
]}

Chen, Bing ^{[4
]}

Hu, Yali ^{[1
]}

Dai, Jianwu ^{[4
]}

Sun, Haixiang ^{[1
]}

机构：

[1] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Obstet & Gynecol, Ctr Reprod Med,Med Sch, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, Affiliated Drum Tower Hosp, Clin Ctr Stem Cell Res, Med Sch, Nanjing 210008, Jiangsu, Peoples R China

[3] Nanjing Univ, Affiliated Drum Tower Hosp, Dept Obstet & Gynecol, Med Sch, Nanjing 210008, Jiangsu, Peoples R China

[4] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100190, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2018年 / 61卷 / 12期

基金：

中国国家自然科学基金;

关键词：

premature ovarian failure; collagen scaffold; UC-MSCs; primordial follicle activation; granulosa cells; FOXO3a; FOXO1; IN-VITRO ACTIVATION; STEM-CELLS; KIT-LIGAND; RAT MODEL; EXPRESSION; FERTILITY; PATHWAY; FOXO3;

D O I：

10.1007/s11427-017-9272-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF.

引用

页码：1554 / 1565

页数：12

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