Continuous theta-burst stimulation over the right dorsolateral prefrontal cortex disrupts fear memory reconsolidation in humans

被引：11

作者：

Su, Sizhen ^{[1
]}

Deng, Jiahui ^{[1
]}

Yuan, Kai ^{[1
]}

Gong, Yimiao ^{[2
,3
]}

Zhang, Yuxin ^{[2
,3
]}

Li, Hui ^{[1
]}

Cao, Kexin ^{[4
,5
]}

Huang, Xiaolin ^{[6
]}

Lin, Xiao ^{[1
]}

Wu, Ping ^{[4
,5
]}

Xue, Yanxue ^{[4
,5
]}

Bao, Yanping ^{[4
,5
]}

Shi, Jie ^{[4
,5
]}

Shi, Le ^{[1
]}

Lu, Lin ^{[1
,2
,3
,4
,5
]}

机构：

[1] Peking Univ, Peking Univ Sixth Hosp, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental, 51 HuayuanBei Rd, Beijing 100191, Peoples R China

[2] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100191, Peoples R China

[3] Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China

[4] Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

[5] Peking Univ, Beijing Key Lab Drug Dependence, Beijing 100191, Peoples R China

[6] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China

来源：

ISCIENCE | 2022年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; RETRIEVAL-EXTINCTION PROCEDURE; LONG-TERM-MEMORY; PROTEIN-SYNTHESIS; PERSISTENT ATTENUATION; COGNITIVE NEUROSCIENCE; BRAIN-STIMULATION; CONSOLIDATION; UPDATE; RETURN;

D O I：

10.1016/j.isci.2021.103614

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Continuous theta-burst stimulation (cTBS), a non-invasive brain stimulation technique, can induce long-lasting changes in synaptic plasticity, vital for memory reconsolidation. For this study, a total of 170 participants completed four experiments by a randomized controlled design. Succeeding fear conditioning, the subjects received cTBS over the right dorsolateral prefrontal cortex (dlPFC) or vertex (control) with or without exposure to the conditioned stimulus to reactivate the original fear memory, and then underwent fear response tests. Compared with cTBS over the vertex and without memory reactivation, only cTBS over the right dlPFC after reactivation decreased the fear response for both recent and remote fear memories. This procedure was effective only during the reconsolidation window. The disruptive effect of cTBS over the right dlPFC on fear memory reconsolidation was delay-dependent. These findings demonstrate that cTBS time-dependently and delay-dependently prevents the return of fear and may have clinical potential for treating fear-related disorders.

引用

页数：16

共 74 条

[21] Characterization of fear memory reconsolidation [J].