Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine

被引：35
|
作者：
Xanthopoulou, M. N.
Hadjikakou, S. K. [1 ]
Hadjiliadis, N.
Kourkoumelis, N.
Milaeva, E. R.
Gracheva, Yu. A.
Tyurin, V. Yu.
Verginadis, I.
Karkabounas, S.
Baril, M.
Butler, I. S.
机构：
[1] Univ Ioannina, Dept Chem, Inorgan & Analyt Chem, GR-45110 Ioannina, Greece
[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia
[3] Univ Ioannina, Sch Med, Dept Expt Physiol, GR-45110 Ioannina, Greece
[4] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
bioinorganic chemistry; complexes; organotin(IV) complexes; 2-mercaptopyrimidine; lipoxygenases; antitumor activity;
D O I：
10.1007/s11172-007-0115-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bu2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1-4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2-4 was demonstrated.
引用
收藏
页码：767 / 773
页数：7
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