Assessing Smoking Status and Risk of SARS-CoV-2 Infection: A Machine Learning Approach among Veterans

被引:2
作者
Djotsa, Alice B. S. Nono [1 ,2 ,3 ]
Helmer, Drew A. [1 ,2 ]
Park, Catherine [1 ,2 ,3 ]
Lynch, Kristine E. [4 ]
Sharafkhaneh, Amir [1 ,2 ]
Naik, Aanand D. [1 ,5 ]
Razjouyan, Javad [1 ,2 ]
Amos, Christopher, I [2 ]
机构
[1] Michael E DeBakey VA Med Ctr, VA HSR&D Ctr Innovat Qual Effectiveness & Safety, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[3] VA Off Res & Dev, Big Data Scientist Training Enhancement Program B, Washington, DC 20571 USA
[4] Univ Utah, VA Salt Lake City Hlth Care Syst, Salt Lake City, UT 84148 USA
[5] UTHlth Sch Publ Hlth, Dept Management Policy & Community Hlth, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
SARS Coronavirus 2; smoking; machine learning; veteran; CIGARETTE-SMOKING; COVID-19; HEALTH; MILITARY; CARE;
D O I
10.3390/healthcare10071244
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
The role of smoking in the risk of SARS-CoV-2 infection is unclear. We used a retrospective cohort design to study data from veterans' Electronic Medical Record to assess the impact of smoking on the risk of SARS-CoV-2 infection. Veterans tested for the SARS-CoV-2 virus from 02/01/2020 to 02/28/2021 were classified as: Never Smokers (NS), Former Smokers (FS), and Current Smokers (CS). We report the adjusted odds ratios (aOR) for potential confounders obtained from a cascade machine learning algorithm. We found a 19.6% positivity rate among 1,176,306 veterans tested for SARS-CoV-2 infection. The positivity proportion among NS (22.0%) was higher compared with FS (19.2%) and CS (11.5%). The adjusted odds of testing positive for CS (aOR:0.51; 95%CI: 0.50, 0.52) and FS (aOR:0.89; 95%CI:0.88, 0.90) were significantly lower compared with NS. Four pre-existing conditions, including dementia, lower respiratory infections, pneumonia, and septic shock, were associated with a higher risk of testing positive, whereas the use of the decongestant drug phenylephrine or having a history of cancer were associated with a lower risk. CS and FS compared with NS had lower risks of testing positive for SARS-CoV-2. These findings highlight our evolving understanding of the role of smoking status on the risk of SARS-CoV-2 infection.
引用
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页数:13
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