Natural products to prevent drug resistance in cancer chemotherapy: a review

被引:169
|
作者
Yuan, Renyikun [1 ]
Hou, Ying [1 ]
Sun, Wen [1 ]
Yu, Jie [1 ]
Liu, Xin [1 ]
Niu, Yanan [1 ]
Lu, Jin-Jian [1 ]
Chen, Xiuping [1 ]
机构
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
关键词
drug resistance; cancer; natural products; nonapoptotic cell death; AUTOPHAGIC CELL-DEATH; OVERCOMING MULTIDRUG-RESISTANCE; MYELOGENOUS LEUKEMIA-CELLS; MALIGNANT GLIOMA-CELLS; BREAST-CANCER; IN-VITRO; MOLECULAR-MECHANISMS; SIGNALING PATHWAYS; JNK ACTIVATION; ROS PRODUCTION;
D O I
10.1111/nyas.13387
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chemotherapy is the standard internal medical treatment for cancer. However, the resistance of cancer cells to nearly all kinds of chemotherapeutic drugs and targeted drugs has become prevalent, and approximately 80-90% of deaths in cancer patients are directly or indirectly attributed to drug resistance. The progress of new drug research and development has also been impeded by the occurrence of drug resistance, which has emerged as a considerable challenge in cancer therapy. Fortunately, natural products with diverse chemical structures and pharmacological effects serve as effective substances against drug resistance. Since the discovery of a series of drug-resistant proteins, drug-efflux inhibition has been applied as the primary strategy to overcome drug resistance by maintaining the intracellular concentrations of chemotherapeutic drugs. Nonapoptotic cell death is considered an alternative strategy because most cases of drug resistance result in evasion and insensitivity to apoptosis. In this concise review, we summarize two strategies using natural products against drug resistance.
引用
收藏
页码:19 / 27
页数:9
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