Long-term outcomes of high dose carbon-ion radiation therapy for unresectable upper cervical (C1-2) chordoma

被引：3

作者：

Aoki, Shuri ^{[1
,2
]}

Koto, Masashi ^{[1
]}

Ikawa, Hiroaki ^{[1
]}

Imai, Reiko ^{[1
]}

Tokuhiko, Omatsu ^{[1
]}

Shinoto, Makoto ^{[1
]}

Takiyama, Hirotoshi ^{[1
]}

Yamada, Shigeru ^{[1
]}

Tsuji, Hiroshi ^{[1
]}

机构：

[1] Natl Inst Quantum Sci & Technol, QST Hosp, Chiba, Japan

[2] Univ Tokyo Hosp, Dept Radiol, Tokyo, Japan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 10期

基金：

日本学术振兴会;

关键词：

carbon-ion radiation therapy; cervical spine; chordoma; myelitis; vertebral compression fractures; SKULL BASE CHORDOMAS; MOBILE SPINE; SACRAL CHORDOMA; PROTON-BEAM; RADIOTHERAPY; MANAGEMENT; PARTICLE; CANCER;

D O I：

10.1002/hed.27127

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Chordoma is a rare, locally invasive neoplasm of the axial skeleton. Complete resection is often difficult, especially for the upper-cervical (C1-2) spine. We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) for unresectable C1-2 chordoma. Methods Patients with C1-2 chordoma treated with definitive CIRT (60.8 Gy [RBE] in 16 fractions) were retrospectively analyzed. We evaluated OS, LC, PFS, and toxicity. Results Nineteen eligible patients all completed the planned course of CIRT. With the median follow-up 68 months (range: 29-144), median OS was 126 months (range: 36-NA). Five-year OS, LC, and PFS were 68.4% (95% CI, 42.8%-84.4%), 75.2% (46.1%-90.0%), and 64.1% (36.3%-82.3%), respectively. Regarding acute toxicity of grade >= 3, there was only one grade 3 mucositis. Late toxicity included radiation-induced myelitis (grade 3 in 1 patient; 5.3%), and compression fractures (n = 5; 26.3%). Conclusions High-dose CIRT is a promising treatment option for unresectable upper cervical chordoma.

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页码：2162 / 2170

页数：9

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