Cardiotoxicity and cardiomyopathy in children and young adult survivors of hematopoietic stem cell transplant

被引：24

作者：

Rotz, Seth J. ^{[1
]}

Ryan, Thomas D. ^{[2
]}

Hlavaty, Joel ^{[1
]}

George, Stephen A. ^{[3
]}

El-Bietar, Javier ^{[1
]}

Dandoy, Christopher E. ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Cardiol, Cincinnati, OH 45229 USA

[3] Univ Minnesota, Div Cardiol, Minneapolis, MN USA

来源：

PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 11期

关键词：

stem cell transplant; late effects; cardiotoxicity; cardiomyopathy; survivors; bmt; CONGESTIVE-HEART-FAILURE; BONE-MARROW-TRANSPLANTATION; VENTRICULAR SYSTOLIC DYSFUNCTION; PULMONARY ARTERIAL-HYPERTENSION; ACUTE LYMPHOBLASTIC-LEUKEMIA; VERSUS-HOST-DISEASE; LONG-TERM SURVIVORS; CARDIAC-FUNCTION; CARDIOVASCULAR-DISEASE; PEDIATRIC-PATIENTS;

D O I：

10.1002/pbc.26600

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cardiomyopathy is common in long-term survivors of pediatric hematopoietic stem cell transplant (HSCT). Events occurring before and after HSCT when combined with specific insults during HSCT likely contribute to long-term risk. Strategies for detecting subclinical cardiomyopathy prior to patients developing overt heart failure are under investigation. Changes in HSCT preparative regimens and cardioprotective medications administered during chemotherapy may alter the risk for cardiomyopathy. Interventions in long-term survivors such as lifestyle modification and cardioactive medications are of increasing importance. Herein we review the causes of cardiac injury, discuss strategies for detection of cardiomyopathy, and evaluate therapeutic options for long-term HSCT survivors.

引用

页数：10

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