Therapy of relapsed Hodgkin lymphoma

被引：9
作者：
Cashen, Amanda F. [1 ]
Bartlett, Nancy L. [1 ]
机构：
[1] Washington Univ, Sch Med, Div Oncol, St Louis, MO 63110 USA
来源：
BLOOD REVIEWS | 2007年 / 21卷 / 05期
关键词：
Hodgkin lymphoma; Autotogous stem cell transplantation; Ailogeneic stem cell transplantation; Salvage therapy;
D O I：
10.1016/j.blre.2007.06.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The majority of patients who are diagnosed with Hodgkin lymphoma (HL) will be cured with primary chemotherapy. For those who relapse, autologous stem cell transplantation (ASCT) has become the standard of care. Randomized clinical trials have demonstrated that approximately 50% of patients with chemosensitive relapsed HL can achieve long term disease free survival with ASCT. However, optimal therapy of those who have chemorefractory disease or who relapse after an ASCT has not been established. Reduced intensity allogeneic stem cell transplantation may benefit these patients, although a definite graft versus HL effect has not been demonstrated and treatment-related mortality remains relatively high. New salvage regimens that incorporate gemcitabine, vinoretbine, rituximab, and/or monoclonal antibodies against CD30 are being investigated. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：233 / 243
页数：11
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