Role of microRNAs in maintaining cancer stem cells

被引：98

作者：

Garofalo, Michela ^{[1
,2
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Univ Manchester, Canc Res UK Manchester Inst, Transcript Networks Lung Canc Grp, Manchester M20 4BX, Lancs, England

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2015年 / 81卷

关键词：

MicroRNAs; Cancer; Cancer stem cells; Embryonic stem cells (ESCs); EMT; EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; HEPATOCELLULAR-CARCINOMA CELLS; TUMOR-INITIATING CELLS; NEGATIVE FEEDBACK LOOP; BREAST-CANCER; SELF-RENEWAL; LUNG-CANCER; STEM/PROGENITOR CELLS; PROGENITOR CELLS;

D O I：

10.1016/j.addr.2014.11.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increasing evidence sustains that the establishment and maintenance of many, if not all, human cancers are due to cancer stem cells (CSCs), tumor cells with stem cell properties, such as the capacity to self-renew or generate progenitor and differentiated cells. CSCs seem to play a major role in tumor metastasis and drug resistance, but albeit the potential clinical importance, their regulation at the molecular level is not clear. Recent studies have highlighted several miRNAs to be differentially expressed in normal and cancer stem cells and established their role in targeting genes and pathways supporting cancer stemness properties. This review focuses on the last advances on the role of microRNAs in the regulation of stem cell properties and cancer stem cells in different tumors. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：53 / 61

页数：9

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