HIV-1 molecular transmission network among sexually transmitted populations in Liaoning Province, China

被引:14
作者
Ma, Ning [1 ]
Chen, Xing-hua [2 ]
Zhao, Yan [1 ]
Kang, Xu [1 ]
Pan, Shan [1 ]
Yao, Wen-qing [1 ]
机构
[1] Liaoning Prov Ctr Dis Control & Prevent, Shenyang 110005, Liaoning, Peoples R China
[2] China Med Univ, Hosp 1, Shenyang, Liaoning, Peoples R China
关键词
gene subtype; human immunodeficiency virus-1; molecular transmission network; sexually transmitted; EXPANDING EPIDEMIC; CRF01-AE; MEN; SEX; MSM;
D O I
10.1097/MD.0000000000026640
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: In recent years, with the development of molecular epidemiology, molecular transmission networks based on evolutionary theory and sequence analysis have been widely used in research on human immunodeficiency virus (HIV)-1 transmission dynamics and precise intervention for high-risk populations. The HIV-1 molecular transmission network is a new method to study the population's access to the network, the characteristics of clustering, and the characteristics of interconnection in the network. Here, we analyzed the characteristics of the HIV-1 molecular transmission network of sexually transmitted people in Liaoning Province. Methods: A study of HIV-infected persons who were sexually transmitted in Liaoning Province from 2003 to 2019. HIV-1 RNA was extracted, amplified and sequenced, and a phylogenetic tree was constructed to determine the subtype using the well matched pol gene region sequence. The gene distance between sequences was calculated, the threshold was determined, and the molecular transmission network was constructed. Results: 109 samples of pol gene region were obtained. The main subtype of HIV-1 was CRF01_AE, followed by B, CRF07_BC, etc. 12.8% of them were resistant to HIV. At the threshold of 0.55 gene distance, 60.6% of them entered the HIV-1 molecular transmission network. Workers, sample source voluntary counseling and testing, other testing, subtype B and drug resistance are the factors influencing the access to HIV-1 molecular transmission network. The subtype of CRF01_AE formed 6 clusters in the molecular transmission network. In the network, the difference of connection degree between different subtypes was statistically significant. Discussion: The three subtypes CRF01_AE, CRF07_BC and B that enter the molecular transmission network do not have interconnections, and they form clusters with each other. It shows that the risk of transmission among the three subtypes is less than the risk of transmission within each subtype. The factors affecting HIV-1 entry into the molecular transmission network were occupation, sample source, genotype and drug resistance. The L33F mutation at the HIV-1 resistance mutation site constitutes the interconnection in the largest transmission cluster in the network. The epidemiological characteristics of HIV-infected persons in each molecular transmission cluster show that 97% of the study subjects come from the same area and have a certain spatial aggregation. Conclusion: Constructing a molecular transmission network and conducting long-term monitoring, while taking targeted measures to block the spread of HIV can achieve precise prevention and control.
引用
收藏
页数:7
相关论文
共 50 条
[41]   Sexually Transmitted Infections Among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data From the DC Cohort [J].
Lucar, Jose ;
Hart, Rachel ;
Rayeed, Nabil ;
Terzian, Arpi ;
Weintrob, Amy ;
Siegel, Marc ;
Parenti, David M. ;
Squires, Leah E. ;
Williams, Rush ;
Castel, Amanda D. ;
Benator, Debra A. .
OPEN FORUM INFECTIOUS DISEASES, 2018, 5 (02)
[42]   Condom use among married women at risk for sexually transmitted infections and HIV in rural China [J].
Hong, Hang ;
Qin, Qi-Rong ;
Li, Lian-Hong ;
Ji, Guo-Ping ;
Ye, Dong-Qing .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2009, 106 (03) :262-265
[43]   HIV-1 transmitted drug resistance-associated mutations and mutation co-variation in HIV-1 treatment-naive MSM from 2011 to 2013 in Beijing, China [J].
Jiao, Yang ;
Li, Shuming ;
Li, Zhenpeng ;
Zhang, Zheng ;
Zhao, Jianhong ;
Li, Li ;
Wang, Lijuan ;
Yin, Qianqian ;
Wang, Yan ;
Zeng, Zhaoli ;
Shao, Yiming ;
Ma, Liying .
BMC INFECTIOUS DISEASES, 2014, 14
[44]   Identification of Multiple Unique HIV-1 Recombinant Forms in Newly Reported HIV-1 Infected Individuals - Anhui Province, China, 2023 [J].
Li, Huan ;
Feng, Yi ;
Li, Qi ;
Wu, Jianjun ;
Xing, Hui ;
Liao, Lingjie ;
Wang, Zheng .
CHINA CDC WEEKLY, 2025, 7 (08) :283-289
[45]   Molecular Epidemiology of HIV-1 in Jilin Province, Northeastern China: Emergence of a New CRF07_BC Transmission Cluster and Intersubtype Recombinants [J].
Li, Xingguang ;
Zang, Xihui ;
Ning, Chuanyi ;
Feng, Yi ;
Xie, Cunxin ;
He, Xiang ;
Takebe, Yutaka ;
Sun, Liuyan ;
Guo, Qi ;
Xing, Hui ;
Kalish, Marcia L. ;
Shao, Yiming .
PLOS ONE, 2014, 9 (10)
[46]   Trends of HIV-1 Subtypes Among Young People in Hangzhou, China [J].
Zhang, Wenjun ;
Chen, Junfang ;
Pan, Xiaohong ;
Zhang, Jiafeng ;
Guo, Zhihong ;
Luo, Yan ;
Yang, Jiezhe ;
Xia, Yan ;
He, Lin ;
Xu, Yun ;
Xu, Ke ;
Ding, Xiaobei .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2017, 33 (03) :219-227
[47]   Young MSM changed temporal HIV-1 epidemic pattern in Heilongjiang Province, China [J].
Li, Qing-Hai ;
Wang, Jia-Ye ;
Liu, Si-Yu ;
Zhang, Yun-Qi ;
Li, En-Long ;
Wang, Yi-Ru ;
Zhang, Shu-Lei ;
Zhao, Wen-Bo ;
Liu, Shu-Lin ;
Chen, Xiao-Hong ;
Wang, Fu-Xiang .
FRONTIERS IN MICROBIOLOGY, 2022, 13
[48]   Epidemiological surveillance of HIV-1 transmitted drug resistance among newly diagnosed individuals in Shijiazhuang, northern China, 2014-2015 [J].
Wang, Xianfeng ;
Liu, Xiaosong ;
Li, Feng ;
Zhou, Hong ;
Li, Jiefang ;
Wang, Yingying ;
Liu, Lihua ;
Liu, Shujun ;
Feng, Yi ;
Wang, Ning .
PLOS ONE, 2018, 13 (06)
[49]   Phylogenetic Analysis of HIV-1 CRF65_CPX Reveals Yunnan Province Is Still a Source Contributing to the Spread of HIV-1 in China [J].
Liu, Yongjian ;
Gui, Tao ;
Jia, Lei ;
Li, Lin ;
Bao, Zuoyi ;
Li, Hanping ;
Wang, Xiaolin ;
Liu, Siyang ;
Zhuang, Daomin ;
Li, Tianyi ;
Li, Jingyun .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2015, 70 (03) :E120-E122
[50]   Migration interacts with the local transmission of HIV in developed trade areas: A molecular transmission network analysis in China [J].
Zhang, Jiafeng ;
Yao, Jiaming ;
Jiang, Jun ;
Pan, Xiaohong ;
Luo, Mingyu ;
Xia, Yan ;
Fan, Qin ;
Ding, Xiaobei ;
Ruan, Jianjun ;
Handel, Andreas ;
Bahl, Justin ;
Chen, Wanjun ;
Zha, Lianqi ;
Fu, Tao .
INFECTION GENETICS AND EVOLUTION, 2020, 84