Comprehensive Analysis of Brain Volume in REM Sleep Behavior Disorder with Mild Cognitive Impairment

被引：29

作者：

Remillard-Pelchat, David ^{[1
,2
]}

Rahayel, Shady ^{[1
,3
]}

Gaubert, Malo ^{[1
,2
]}

Postuma, Ronald B. ^{[1
,4
,5
]}

Montplaisir, Jacques ^{[1
,6
]}

Pelletier, Amelie ^{[1
,5
]}

Monchi, Oury ^{[7
,8
,9
,10
]}

Brambati, Simona Maria ^{[11
,12
]}

Carrier, Julie ^{[1
,11
,12
]}

Gagnon, Jean-Francois ^{[1
,2
,11
]}

机构：

[1] Hop Sacre Coeur Montreal, Ctr Adv Res Sleep Med, Ctr Integre Univ Sante & Serv Sociaux Nord De Ile, Montreal, PQ, Canada

[2] Univ Quebec Montreal, Dept Psychol, Montreal, PQ, Canada

[3] McGill Univ, Montreal Neurol Inst & Hosp, Montreal, PQ, Canada

[4] Montreal Gen Hosp, Dept Neurol, Montreal, PQ, Canada

[5] McGill Univ, Hlth Ctr, Res Inst, Montreal, PQ, Canada

[6] Univ Montreal, Dept Psychiat, Montreal, PQ, Canada

[7] Univ Montreal, Dept Radiol Radiooncol & Nucl Med, Montreal, PQ, Canada

[8] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[9] Univ Calgary, Dept Radiol, Calgary, AB, Canada

[10] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[11] Inst Univ Geriatr Montreal, Res Ctr, Montreal, PQ, Canada

[12] Univ Montreal, Dept Psychol, Montreal, PQ, Canada

来源：

JOURNAL OF PARKINSONS DISEASE | 2022年 / 12卷 / 01期

基金：

加拿大健康研究院;

关键词：

REM sleep behavior disorder; mild cognitive impairment; Parkinson's disease/parkinsonism; dementia with Lewy bodies; magnetic resonance imaging; PARKINSONS-DISEASE; LEWY BODIES; SUPERIOR COLLICULUS; DEMENTIA; ATROPHY; GRAY; SEGMENTATION; METAANALYSIS; MAPS;

D O I：

10.3233/JPD-212691

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Rapid-eye-movement sleep behavior disorder (RBD) is a major risk factor for Parkinson's disease and dementia with Lewy bodies. More than a third of RBD patients have mild cognitive impairment (MCI), but their specific structural brain alterations remain poorly understood. Objective: This study aimed to investigate the local deformation and volume of gray and white matter tissue underlying MCI in RBD. Methods: Fifty-two idiopathic RBD patients, including 17 with MCI (33%), underwent polysomnography, neuropsychological, neurological, and magnetic resonance imaging assessments. MCI diagnosis was based on a subjective complaint, cognitive impairment on the neuropsychological battery, and preserved daily functioning. Forty-one controls were also included. Deformation-based morphometry (DBM), voxel-based morphometry (VBM), and regional volume analyses of the corpus callosum and cholinergic basal forebrain were performed. Multiple regression models were also computed using anatomical, cognitive (composite z scores), and motor parameters. Results: Globally, patients with MCI displayed a widespread pattern of local deformation and volume atrophy in the cortical (bilateral insula, cingulate cortex, precuneus, frontal, temporal and occipital regions, right angular gyrus, and mid-posterior segment of the corpus callosum) and subcortical (brainstem, corona radiata, basal ganglia, thalamus, amygdala, and right hippocampus) regions compared to patients without MCI (DBM) or controls (DBM and VBM). Moreover, brain deformation (DBM) in patients were associated with lower performance in attention and executive functions, visuospatial abilities, and higher motor symptoms severity. Conclusion: The present study identified novel brain structural alterations in RBD patients with MCI which correlated with poorer cognitive performance. These results are consistent with those reported in patients with synucleinopathies-related cognitive impairment.

引用

页码：229 / 241

页数：13

共 58 条

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