A role for brain-derived neurotrophic factor in B cell development

被引：74

作者：

Schuhmann, B

Dietrich, A

Sel, S

Hahn, C

Klingenspor, M

Lommatzsch, M

Gudermann, T

Braun, A

Renz, H

Nockher, WA

机构：

[1] Univ Marburg, Dept Clin Chem & Mol Diagnost, Univ Hosp, D-35033 Marburg, Germany

[2] Univ Marburg, Inst Pharmacol & Toxicol, D-35033 Marburg, Germany

[3] Univ Marburg, Dept Biol, D-35033 Marburg, Germany

[4] Univ Med Clin, Dept Pneumol, D-18055 Rostock, Germany

[5] Fraunhofer Inst Toxicol & Expt Med, Dept Immunol & Allergol, D-30625 Hannover, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 163卷 / 1-2期

关键词：

neurotrophins; brain-derived neurotrophic factor; hematopoesis; bone marrow stromal cells; neuroimmunology;

D O I：

10.1016/j.jneuroim.2005.01.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75(NTR) and TrkB(gp95), while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+](i) in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：15 / 23

页数：9

共 50 条

[41] Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain
Monnier, A.
Prigent-Tessier, A.
Quirie, A.
Bertrand, N.
Savary, S.
Gondcaille, C.
Garnier, P.
Demougeot, C.
Marie, C.
ACTA PHYSIOLOGICA, 2017, 219 (04) : 790 - 802
[42] The Role of Brain-derived Neurotrophic Factor in Mouse Oocyte Maturation in vitro
Zhang, Ling
Li, Jie
Su, Ping
Xiong, Chengliang
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2010, 30 (06) : 781 - 785
[43] Brain-derived neurotrophic factor in human platelets
PliegoRivero, FB
Bayatti, N
Giannakoulopoulos, X
Glover, V
Bradford, HF
Stern, G
Sandler, M
BIOCHEMICAL PHARMACOLOGY, 1997, 54 (01) : 207 - 209
[44] Brain-derived neurotrophic factor in primary headaches
Fischer, Marlene
Wille, Georg
Klien, Stephanie
Shanib, Hind
Holle, Dagny
Gaul, Charly
Broessner, Gregor
JOURNAL OF HEADACHE AND PAIN, 2012, 13 (06) : 469 - 475
[45] Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development
Germana, A.
Sanchez-Ramos, C.
Guerrera, M. C.
Calavia, M. G.
Navarro, M.
Zichichi, R.
Garcia-Suarez, O.
Perez-Pinera, P.
Vega, Jose A.
JOURNAL OF ANATOMY, 2010, 217 (03) : 214 - 222
[46] THE ROLE OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN TRANSIENT FOREBRAIN ISCHEMIA IN THE RAT-BRAIN
TSUKAHARA, T
YONEKAWA, Y
TANAKA, K
OHARA, O
WATANABE, S
KIMURA, T
NISHIJIMA, T
TANIGUCHI, T
NEUROSURGERY, 1994, 34 (02) : 323 - 331
[47] Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Bruno Lima Giacobbo
Janine Doorduin
Hans C. Klein
Rudi A. J. O. Dierckx
Elke Bromberg
Erik F. J. de Vries
Molecular Neurobiology, 2019, 56 : 3295 - 3312
[48] Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Giacobbo, Bruno Lima
Doorduin, Janine
Klein, Hans C.
Dierckx, Rudi A. J. O.
Bromberg, Elke
de Vries, Erik F. J.
MOLECULAR NEUROBIOLOGY, 2019, 56 (05) : 3295 - 3312
[49] ASSOCIATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR AND TYROSINE KINASE B RECEPTOR IN PREGNANCY
Dhobale, M.
Mehendale, S.
Pisal, H.
D'Souza, V.
Joshi, S.
NEUROSCIENCE, 2012, 216 : 31 - 37
[50] Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease
Pragya Girotra
Tapan Behl
Aayush Sehgal
Sukhbir Singh
Simona Bungau
Journal of Molecular Neuroscience, 2022, 72 : 173 - 186

← 1 2 3 4 5 →