A role for brain-derived neurotrophic factor in B cell development

被引：74
|
作者：
Schuhmann, B
Dietrich, A
Sel, S
Hahn, C
Klingenspor, M
Lommatzsch, M
Gudermann, T
Braun, A
Renz, H
Nockher, WA
机构：
[1] Univ Marburg, Dept Clin Chem & Mol Diagnost, Univ Hosp, D-35033 Marburg, Germany
[2] Univ Marburg, Inst Pharmacol & Toxicol, D-35033 Marburg, Germany
[3] Univ Marburg, Dept Biol, D-35033 Marburg, Germany
[4] Univ Med Clin, Dept Pneumol, D-18055 Rostock, Germany
[5] Fraunhofer Inst Toxicol & Expt Med, Dept Immunol & Allergol, D-30625 Hannover, Germany
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 163卷 / 1-2期
关键词：
neurotrophins; brain-derived neurotrophic factor; hematopoesis; bone marrow stromal cells; neuroimmunology;
D O I：
10.1016/j.jneuroim.2005.01.023
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75(NTR) and TrkB(gp95), while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+](i) in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：15 / 23
页数：9
相关论文
共 50 条
  • [31] Brain-derived neurotrophic factor: findings in schizophrenia
    Buckley, Peter F.
    Pillai, Anilkumar
    Howell, Kristy R.
    CURRENT OPINION IN PSYCHIATRY, 2011, 24 (02) : 122 - 127
  • [32] The effect of brain-derived neurotrophic factor on angiogenesis
    Chunyan Sun
    Yu Hu
    Zhangbo Chu
    Jing Huang
    Lu Zhang
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2009, 29 : 139 - 143
  • [33] Brain-derived neurotrophic factor in Huntington disease
    Ferrer, I
    Goutan, E
    Marín, C
    Rey, MJ
    Ribalta, T
    BRAIN RESEARCH, 2000, 866 (1-2) : 257 - 261
  • [34] Cloning of Brain-derived Neurotrophic Factor Gene
    余云开
    华仲慰
    郭建荣
    李玉书
    汪家政
    Chinese Science Bulletin, 1994, (05) : 435 - 439
  • [35] The role of brain-derived neurotrophic factor in mouse oocyte maturation in vitro
    Ling Zhang
    Jie Li
    Ping Su
    Chengliang Xiong
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2010, 30 : 781 - 785
  • [36] Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development
    Suzuki, Shingo
    Kiyosue, Kazuyuki
    Hazama, Shunsuke
    Ogura, Akihiko
    Kashihara, Megumi
    Hara, Tomoko
    Koshimizu, Hisatsugu
    Kojima, Masami
    JOURNAL OF NEUROSCIENCE, 2007, 27 (24) : 6417 - 6427
  • [37] Role of brain-derived neurotrophic factor in target invasion in the gustatory system
    Ringstedt, T
    Ibanez, CF
    Nosrat, CA
    JOURNAL OF NEUROSCIENCE, 1999, 19 (09) : 3507 - 3518
  • [38] Brain-derived neurotrophic factor and suicide pathogenesis
    Dwivedi, Yogesh
    ANNALS OF MEDICINE, 2010, 42 (02) : 87 - 96
  • [39] The effect of brain-derived neurotrophic factor on angiogenesis
    Sun, Chunyan
    Hu, Yu
    Chu, Zhangbo
    Huang, Jing
    Zhang, Lu
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2009, 29 (02) : 139 - 143
  • [40] Brain-derived neurotrophic factor and mental disorders
    Lin, Chin-Chuen
    Huang, Tiao-Lai
    BIOMEDICAL JOURNAL, 2020, 43 (02) : 134 - 142
12345