Emerging Therapeutic Options in Age-Related Macular Degeneration

被引：9
|
作者：
Querques, Giuseppe [1 ,2 ]
Capuano, Vittorio [1 ]
Frascio, Pietro [1 ,3 ]
Bandello, Francesco [2 ]
Souied, Eric H. [1 ]
机构：
[1] Univ Paris Est Creteil, Ctr Hosp Intercommunal Creteil, Serv Ophthalmol, Creteil, France
[2] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, IRCCS, Dept Ophthalmol, Milan, Italy
[3] Univ Genoa, Dept Ophthalmol, Genoa, Italy
来源：
OPHTHALMIC RESEARCH | 2015年 / 53卷 / 04期
关键词：
Age-related macular degeneration; Steroids; Zimura; Fovista; POT-4; Abicipar pegol; Pazopanib; Anti-VEGF drugs; Anti-PDGF drugs; Encapsulated cell technology; FOCUS;
D O I：
10.1159/000379754
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Intravitreal injection of anti-VEGF drugs currently represents the standard of treatment for exudative age-related macular degeneration. Several therapeutic options including steroids, inhibitors of complement factors, anti-platelet-derived growth factor agents, new anti-VEGF drugs, designed ankyrin repeat proteins, sustained drug delivery devices as an alternative to intravitreal injections and encapsulated cell technology are the objects of several studies and trials worldwide in association with anti-VEGF therapy or not. Expectations are that such efforts will help overcome limitations of current therapy with anti-VEGF, extending the duration of effects and hopefully contributing to the regression of neovascular lesions. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：194 / 199
页数：6
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