The Antagonistic Effects of Selenium Yeast (SeY) on Cadmium-Induced Inflammatory Factors and the Heat Shock Protein Expression Levels in Chicken Livers

被引:23
作者
Wang, Yong [1 ]
Liu, Junfeng [1 ]
Chen, Rong [1 ]
Qi, Meng [1 ]
Tao, Dayong [1 ]
Xu, Shiwen [1 ]
机构
[1] Tarim Univ, Coll Anim Sci, Alar 843300, Xinjiang Uygur, Peoples R China
基金
中国国家自然科学基金;
关键词
Cadmium; Selenium yeast; Inflammatory factors; Heat shock proteins; Chicken liver; INDUCED OXIDATIVE STRESS; GENE-EXPRESSION; NITRIC-OXIDE; INDUCED APOPTOSIS; PATHWAY; DAMAGE; DEFICIENCY; SELENOPROTEINS; LYMPHOCYTES; TOXICITY;
D O I
10.1007/s12011-020-02039-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cadmium (Cd) is a ubiquitous toxic heavy metal in the natural environment that can cause multiple organ damage to the bodies of animals and humans. Selenium yeast (SeY) is a kind of organic selenium (Se) that has a very strong function against Cd-induced injury to tissues or organs. The aim of the current study was to investigate the roles of inflammatory factors and heat shock proteins (HSPs) in inflammatory injury triggered by Cd and to analyze the protective effects of SeY on Cd-induced damnification in the livers of chickens. Two hundred 120-day-old layers were randomly divided into four groups and raised on a conventional diet, or with Se (0.5 mg/kg SeY), Cd (150 mg/kg CdCl2), or Se + Cd (0.5 mg/kg SeY and 150 mg/kg CdCl2) in their basic diets for 120 days. Then, the liver histopathology, production of nitric oxide (NO), activity of inducible NO synthase (iNOS), and mRNA and protein expression levels of inflammatory factors (iNOS, NF-kappa B, TNF-alpha, and PTGE) and heat shock proteins (HSPs 27, 40, 60, 70, and 90) were examined. The results showed that exposure to Cd obviously increased Cd accumulation, NO production, iNOS activity, inflammatory factor, and HSP mRNA and protein expression levels and further caused an inflammatory response. Supplementation with SeY had an antagonistic effect on Cd-induced inflammatory injury in chicken livers. Thus, the present study suggests that SeY can be taken as a potential therapeutic for Cd-induced liver inflammatory injury in chickens.
引用
收藏
页码:260 / 268
页数:9
相关论文
共 47 条
[1]   Rutin- and Selenium-attenuated cadmium-induced testicular pathophysiology in rats [J].
Abarikwu, S. O. ;
Iserhienrhien, B. O. ;
Badejo, T. A. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2013, 32 (04) :395-406
[2]   Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2 [J].
Chander, Krishan ;
Vaibhav, Kumar ;
Ahmed, Md. Ejaz ;
Javed, Hayate ;
Tabassum, Rizwana ;
Khan, Andleeb ;
Kumar, Mukesh ;
Katyal, Anju ;
Islam, Fakhrul ;
Siddiqui, M. Saeed .
FOOD AND CHEMICAL TOXICOLOGY, 2014, 68 :297-306
[3]   Involvement of mitochondrial pathway in environmental metal pollutant lead-induced apoptosis of chicken liver: perspectives from oxidative stress and energy metabolism [J].
Chi, Qianru ;
Liu, Tianqi ;
Sun, Zhepeng ;
Tan, Siran ;
Li, Shiping ;
Li, Shu .
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2017, 24 (36) :28121-28131
[4]   In vivo assessment of molybdenum and cadmium co-induced the mRNA levels of heat shock proteins, inflammatory cytokines and apoptosis in shaoxing duck (Anas platyrhyncha) testicles [J].
Dai, Xueyan ;
Nie, Gaohui ;
Cao, Huabin ;
Xing, Chenghong ;
Hu, Guoliang ;
Zhang, Caiying .
POULTRY SCIENCE, 2019, 98 (11) :5424-5431
[5]   Risk of infection associated with anti-TNF-α therapy [J].
Fernandez-Ruiz, Mario ;
Maria Aguado, Jose .
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2018, 16 (12) :939-956
[6]   Cadmium-induced oxidative stress and histological damage in the myocardium. Effects of a soy-based diet [J].
Ferramola, Mariana L. ;
Perez Diaz, Matias F. F. ;
Honore, Stella M. ;
Sanchez, Sara S. ;
Anton, Rosa I. ;
Anzulovich, Ana C. ;
Gimenez, Maria S. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 265 (03) :380-389
[7]   Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis [J].
Gong, Zhong-Gui ;
Wang, Xin-Yu ;
Wang, Jun-Hong ;
Fan, Rui-Feng ;
Wang, Lin .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2019, 192 :62-71
[8]   H2S inhalation-induced energy metabolism disturbance is involved in LPS mediated hepatocyte apoptosis through mitochondrial pathway [J].
Guo, Jinming ;
Xing, Houjuan ;
Chen, Menghao ;
Wang, Wei ;
Zhang, Hongfu ;
Xu, Shiwen .
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 663 :380-386
[9]   Atmospheric H2S triggers immune damage by activating the TLR-7/MyD88/NF-κB pathway and NLRP3 inflammasome in broiler thymus [J].
Hu, Xueyuan ;
Chi, Qianru ;
Liu, Qingqing ;
Wang, Dongxu ;
Zhang, Yiming ;
Li, Shu .
CHEMOSPHERE, 2019, 237
[10]   Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy [J].
Jiang, Tingting ;
Chang, Qing ;
Cai, Jiyang ;
Fan, Jiawen ;
Zhang, Xiaozhe ;
Xu, Gezhi .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016