Contractility and inhibition of protein phosphatases by cantharidin

被引：36

作者：

Knapp, J ^{[1
]}

Bokník, P ^{[1
]}

Huke, S ^{[1
]}

Gombosová, I ^{[1
]}

Linck, B ^{[1
]}

Lüss, H ^{[1
]}

Müller, FU ^{[1
]}

Müller, T ^{[1
]}

Nacke, P ^{[1
]}

Schmitz, W ^{[1
]}

Vahlensieck, U ^{[1
]}

Neumann, J ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmakol & Toxikol, D-48129 Munster, Germany

来源：

GENERAL PHARMACOLOGY | 1998年 / 31卷 / 05期

关键词：

phosphorylation-dephosphorylation; serine/threonine protein phosphatases; cantharidin; cantharidic acid; endothall;

D O I：

10.1016/S0306-3623(98)00053-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Cantharidin is a natural defensive toxicant: produced by blister beetles. 2. Cantharidin shares structural similarity with highly toxic commercial herbicides (e.g., endothall, endothall anhydride and endothall thioanhydride), 3. Cantharidin inhibits the activity of purified catalytic subunits of serine/threonine protein phosphatases (PP) type 1 and type 2A. 4. Cantharidin increases force of contraction in isolated myocardial and vascular preparations. 5. Cantharidin enhances the phosphorylation state of myocardial and vascular regulatory proteins. 6. Cantharidin is a valuable tool for studying the function of PP in regulatory phosphorylation-dephosphorylation events. (C) 1998 Elsevier Science Inc.

引用

页码：729 / 733

页数：5

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