Contractility and inhibition of protein phosphatases by cantharidin

被引：36

作者：

Knapp, J ^{[1
]}

Bokník, P ^{[1
]}

Huke, S ^{[1
]}

Gombosová, I ^{[1
]}

Linck, B ^{[1
]}

Lüss, H ^{[1
]}

Müller, FU ^{[1
]}

Müller, T ^{[1
]}

Nacke, P ^{[1
]}

Schmitz, W ^{[1
]}

Vahlensieck, U ^{[1
]}

Neumann, J ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmakol & Toxikol, D-48129 Munster, Germany

来源：

GENERAL PHARMACOLOGY | 1998年 / 31卷 / 05期

关键词：

phosphorylation-dephosphorylation; serine/threonine protein phosphatases; cantharidin; cantharidic acid; endothall;

D O I：

10.1016/S0306-3623(98)00053-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Cantharidin is a natural defensive toxicant: produced by blister beetles. 2. Cantharidin shares structural similarity with highly toxic commercial herbicides (e.g., endothall, endothall anhydride and endothall thioanhydride), 3. Cantharidin inhibits the activity of purified catalytic subunits of serine/threonine protein phosphatases (PP) type 1 and type 2A. 4. Cantharidin increases force of contraction in isolated myocardial and vascular preparations. 5. Cantharidin enhances the phosphorylation state of myocardial and vascular regulatory proteins. 6. Cantharidin is a valuable tool for studying the function of PP in regulatory phosphorylation-dephosphorylation events. (C) 1998 Elsevier Science Inc.

引用

页码：729 / 733

页数：5

共 50 条

[1] THE CONTROL OF PROTEIN PHOSPHATASE-1 BY TARGETING SUBUNITS - THE MAJOR MYOSIN PHOSPHATASE IN AVIAN SMOOTH-MUSCLE IS A NOVEL FORM OF PROTEIN PHOSPHATASE-1
ALESSI, D
MACDOUGALL, LK
SOLA, MM
IKEBE, M
COHEN, P
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 210 (03): : 1023 - 1035
[2] BERTAUX B, 1987, BRIT J DERMATOL, V118, P157
[3] DECREASED CATECHOLAMINE SENSITIVITY AND BETA-ADRENERGIC-RECEPTOR DENSITY IN FAILING HUMAN HEARTS
BRISTOW, MR
GINSBURG, R
MINOBE, W
CUBICCIOTTI, RS
SAGEMAN, WS
LURIE, K
BILLINGHAM, ME
HARRISON, DC
STINSON, EB
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (04) : 205 - 211
[4] CHENG XC, 1990, J ANTIBIOT, V43, P809, DOI 10.7164/antibiotics.43.809
[5] THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES
COHEN, P
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 : 453 - 508
[6] CANTHARIDIN EFFECTS ON PROTEIN PHOSPHATASES AND THE PHOSPHORYLATION STATE OF PHOSPHOPROTEINS IN MICE
ELDRIDGE, R
CASIDA, JE
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1995, 130 (01) : 95 - 100
[7] ERDODI F, 1996, BIOCH SMOOTH MUSCLE, P131
[8] INCREASE OF THE 40,000-MOL WT PERTUSSIS TOXIN SUBSTRATE (G-PROTEIN) IN THE FAILING HUMAN-HEART
FELDMAN, AM
CATES, AE
VEAZEY, WB
HERSHBERGER, RE
BRISTOW, MR
BAUGHMAN, KL
BAUMGARTNER, WA
VANDOP, C
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (01) : 189 - 197
[9] GONG MC, 1992, J BIOL CHEM, V267, P14662
[10] EFFECTS OF A PROTEIN PHOSPHATASE INHIBITOR, OKADAIC ACID, ON MEMBRANE CURRENTS OF ISOLATED GUINEA-PIG CARDIAC MYOCYTES
HESCHELER, J
MIESKES, G
RUEGG, JC
TAKAI, A
TRAUTWEIN, W
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1988, 412 (03): : 248 - 252

← 1 2 3 4 5 →