Asymmetric synthesis of tertiary thiols and thioethers

被引：183
作者：
Clayden, Jonathan [1 ]
MacLellan, Paul [1 ]
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 7卷
关键词：
asymmetric synthesis; organolithium; sulfur; substitution; thiol; OXIDATION-REDUCTION CONDENSATION; ALKYL ARYL SULFIDES; HIGHLY ENANTIOSELECTIVE REACTIONS; STEREOCHEMICAL COURSE; ALPHA-ARYLATION; CONFIGURATIONAL STABILITY; STEREOSPECIFIC SYNTHESIS; ENANTIOMERICALLY PURE; CARBOXYLIC-ACIDS; BOND FORMATION;
D O I：
10.3762/bjoc.7.68
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available.
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收藏
页码：582 / 595
页数：14
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