The nature and identification of quantitative trait loci: a community's view

被引:297
作者
Abiola, O
Angel, JM
Avner, P
Bachmanov, AA
Belknap, JK
Bennett, B
Blankenhorn, EP
Blizard, DA
Bolivar, V
Brockmann, GA
Buck, KJ
Bureau, JF
Casley, WL
Chesler, EJ
Cheverud, JM
Churchill, GA
Cook, M
Crabbe, JC
Crusio, WE
Darvasi, A
de Haan, G
Demant, P
Doerge, RW
Elliott, RW
Farber, CR
Flaherty, L
Flint, J
Gershenfeld, H
Gu, JPGJ
Gu, WK
Himmelbauer, H
Hitzemann, R
Hsu, HC
Hunter, K
Iraqi, FA
Jansen, RC
Johnson, TE
Jones, BC
Kempermann, G
Lammert, F
Lu, L
Manly, KF
Matthews, DB
Medrano, JF
Mehrabian, M
Mittleman, G
Mock, BA
Mogil, JS
Montagutelli, X
Morahan, G
机构
[1] Institute of Psychiatry, King's College London, London SE5 8AF, De'Crespigny Park, Denmark Hill
[2] University of Texas Maryland Anderson Cancer Center, Science Park-Research Division, Smithville
[3] Unité Génétique Moléculaire Murine, 75015 Paris, Institut Pasteur, 25, rue du Docteur Roux
[4] Monell Chemical Senses Center, Philadelphia 19104
[5] Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland
[6] Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia 19129
[7] Center for Developmental and Health Genetics, Pennsylvania State University, Pennsylvania 16802,, University Park
[8] Genomics Institute, Wadsworth Center, Troy,New York 12180
[9] Research Institute for the Biology of Farm Animals, Department of Molecular Biology, 18196 Dummerstorf
[10] Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University and VAMC, Portland
[11] Unite des Virus Lents, Institut Pasteur, 75724 Paris, Cedex 15
[12] Centre for Biologics Research, Health Canada, Ottawa, Ontario K1A 0L2
[13] University of Tennessee, Department of Anatomy and Neurobiology, Memphis, Tennessee 38163, Room 515
[14] Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110
[15] Jackson Laboratory, Bar Harbor
[16] Department of Psychology, University of Memphis, Memphis
[17] Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University and VAMC, Portland
[18] Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604
[19] Life Sciences Institute, Hebrew University
[20] Groningen Bioinformatics Centre, University of Groningen, Groningen, PO Box 800
[21] Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo
[22] Department of Statistics, Purdue University, West Lafayette, Indiana 47907
[23] Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo
[24] Department of Animal Science, University of California at Davis, Davis, California 95616, One Shields Avenue
[25] Genomics Institute, Wadsworth Center, Troy, New York 12180
[26] Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, Roosevelt Drive
[27] University of Texas Southwestern Medical Center, Dallas, Texas 75390
[28] International Livestock Research Institute, Nairobi
[29] Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163
[30] Center of Genomics and Bioinformatics & Center of Diseases of Connective Tissues, Department of Orthopaedic Surgery, University of Tennessee Health Science Center, Memphis
[31] Max-Planck-Institute of Molecular Genetics, D-14195 Berlin
[32] Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland
[33] University of Alabama at Birmingham, Birmingham, Alabama 35294
[34] Laboratory of Population Genetics, CCR/NCI/NIH, Bethesda,Maryland 20892, Building 41
[35] International Livestock Research Institute, Nairobi
[36] Groningen Bioinformatics Centre, University of Groningen, Groningen PO Box 800
[37] Institute for Behavioral Genetics, Box 447, University of Colorado, Boulder
[38] Department of Biobehavioral Health, Pennsylvania State University, University Park
[39] Forschungsgruppe der VolkswagenStiftung, 'Neurogene Permissivität' Neurologische Universitätsklinik der Charité, Humboldt-Universität zu Berlin Forschungsgruppe 'Neuronale Stammzellen', Robert-Rössle-Street 10, 13125 Berlin, Max-Delbrück-Centrum für Moleku
[40] Department of Medicine III, University Hospital Aachen, Aachen University, 52057 Aachen
[41] Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163
[42] Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo
[43] Department of Psychology, University of Memphis, Memphis
[44] Department of Animal Science, University of California, Davis, California 95616, One Shields Avenue
[45] UCLA, Department of Medicine/Cardiology, Los Angeles, California 90095
[46] Department of Psychology, University of Memphis, Memphis
[47] Building 37, Laboratory of Genetics, NCI, NIH, Bethesda
[48] Department of Psychology, McGill University, Montreal, Quebec H3A 1B1
[49] Unité de Génétique des Mammifères, Institut Pasteur, 75724 Paris, Cedex 15
[50] Complex Genetic Diseases Unit, Australian Type 1 Diabetes DNA Repository, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, PO Royal Melbourne Hospital
关键词
D O I
10.1038/nrg1206
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?
引用
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页码:911 / 916
页数:6
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