The Combination of Radiotherapy With Immunotherapy and Potential Predictive Biomarkers for Treatment of Non-Small Cell Lung Cancer Patients

被引：31

作者：

Meng, Lu ^{[1
]}

Xu, Jianfang ^{[2
]}

Ye, Ying ^{[1
]}

Wang, Yingying ^{[1
]}

Luo, Shilan ^{[1
]}

Gong, Xiaomei ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Pulm Hosp, Dept Radiat Oncol, Sch Med, Shanghai, Peoples R China

[2] Tongji Univ, Shanghai Pulm Hosp, Dept Oncol, Sch Med, Shanghai, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

non-small cell lung cancer (NSCLC); radiotherapy; immunotherapy; immune checkpoint inhibitor (ICI); biomarker; REGULATORY T-CELLS; ABLATIVE RADIATION-THERAPY; TUMOR MUTATIONAL BURDEN; LIGAND; EXPRESSION; CHECKPOINT BLOCKADE; PERIPHERAL-BLOOD; CTLA-4; BLOCKADE; PD-1; OPEN-LABEL; NIVOLUMAB;

D O I：

10.3389/fimmu.2021.723609

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Radiotherapy is an effective local treatment modality of NSCLC. Its capabilities of eliminating tumor cells by inducing double strand DNA (dsDNA) damage and modulating anti-tumor immune response in irradiated and nonirradiated sites have been elucidated. The novel ICIs therapy has brought hope to patients resistant to traditional treatment methods, including radiotherapy. The integration of radiotherapy with immunotherapy has shown improved efficacy to control tumor progression and prolong survival in NSCLC. In this context, biomarkers that help choose the most effective treatment modality for individuals and avoid unnecessary toxicities caused by ineffective treatment are urgently needed. This article summarized the effects of radiation in the tumor immune microenvironment and the mechanisms involved. Outcomes of multiple clinical trials investigating immuno-radiotherapy were also discussed here. Furthermore, we outlined the emerging biomarkers for the efficacy of PD-1/PD-L1 blockades and radiation therapy and discussed their predictive value in NSCLC.</p>

引用

页数：16

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