Sarcopenia: Etiology, Nutritional Approaches, and miRNAs

被引：122

作者：

Cannataro, Roberto ^{[1
,2
,3
]}

Carbone, Leandro ^{[3
,4
]}

Petro, Jorge L. ^{[3
,5
]}

Cione, Erika ^{[1
,2
]}

Vargas, Salvador ^{[3
,6
]}

Angulo, Heidy ^{[7
]}

Forero, Diego A. ^{[8
]}

Odriozola-Martinez, Adrian ^{[9
,10
]}

Kreider, Richard B. ^{[11
]}

Bonilla, Diego A. ^{[3
,5
,10
,12
]}

机构：

[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[2] Univ Calabria, Galascreen Labs, I-87036 Arcavacata Di Rende, Italy

[3] DBSS Int SAS, Res Div, Dynam Business & Sci Soc, Bogota 110311, Colombia

[4] Univ Salvador, Fac Med, RA-1020 Buenos Aires, DF, Argentina

[5] Univ Cordoba, Res Grp Phys Act Sports & Hlth Sci GICAFS, Monteria 230002, Colombia

[6] EADE Univ Wales Trinity St David, Fac Sport Sci, Malaga 29018, Spain

[7] Corp Univ Rafael Nunez, Grp Invest Programa Med GINUMED, Cartagena 130001, Colombia

[8] Fdn Univ Area Andina, Sch Hlth & Sport Sci, Hlth & Sport Sci Res Grp, Bogota 111221, Colombia

[9] Univ Basque Country, UPV EHU, Dept Genet Phys Anthropol & Anim Physiol, Sport Genom Res Grp, Leioa 48940, Spain

[10] Univ Basque Country, UPV EHU, Joxe Mari Korta Res Ctr, kDNA Genom, Donostia San Sebastian 20018, Spain

[11] Texas A&M Univ, Exercise & Sport Nutr Lab, Human Clin Res Facil, College Stn, TX 77843 USA

[12] Univ Dist Francisco Jose de Caldas, Res Grp Biochem & Mol Biol, Bogota 110311, Colombia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 18期

关键词：

mitochondria; aging; protein; muscle; nutritional supplements; MyomiR; HYDROXY-BETA-METHYLBUTYRATE; MYOFIBRILLAR PROTEIN-SYNTHESIS; LOW-GRADE INFLAMMATION; RESISTANCE EXERCISE; OXIDATIVE STRESS; VITAMIN-D; MITOCHONDRIAL-FUNCTION; AMINO-ACIDS; NUTRIENT AVAILABILITY; SATELLITE CELL;

D O I：

10.3390/ijms22189724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial syndrome, the etiology and underlying mechanisms are not yet delineated. Moreover, research about nutritional interventions to prevent the development of sarcopenia is mainly focused on the amount and quality of protein intake. The impact of several nutrition strategies that consider timing of food intake, anti-inflammatory nutrients, metabolic control, and the role of mitochondrial function on the progression of sarcopenia is not fully understood. This narrative review summarizes the metabolic background of this phenomenon and proposes an integral nutritional approach (including dietary supplements such as creatine monohydrate) to target potential molecular pathways that may affect reduce or ameliorate the adverse effects of sarcopenia. Lastly, miRNAs, in particular those produced by skeletal muscle (MyomiR), might represent a valid tool to evaluate sarcopenia progression as a potential rapid and early biomarker for diagnosis and characterization.

引用

页数：19

共 184 条

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