3D printed personalized magnetic micromachines from patient blood-derived biomaterials

被引:68
作者
Ceylan, Hakan [1 ]
Dogan, Nihal Olcay [1 ,2 ]
Yasa, Immihan Ceren [1 ]
Musaoglu, Mirac Nur [1 ,3 ,4 ]
Kulali, Zeynep Umut [1 ,3 ,4 ]
Sitti, Metin [1 ,2 ,3 ,4 ]
机构
[1] Max Planck Inst Intelligent Syst, Phys Intelligence Dept, D-70569 Stuttgart, Germany
[2] Swiss Fed Inst Technol, Inst Biomed Engn, CH-8092 Zurich, Switzerland
[3] Koc Univ, Sch Med, TR-34450 Istanbul, Turkey
[4] Koc Univ, Coll Engn, TR-34450 Istanbul, Turkey
基金
欧洲研究理事会;
关键词
MICROROBOTS; PRINCIPLES; COLLAGEN;
D O I
10.1126/sciadv.abh0273
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
While recent wireless micromachines have shown increasing potential for medical use, their potential safety risks concerning biocompatibility need to be mitigated. They are typically constructed from materials that are not intrinsically compatible with physiological environments. Here, we propose a personalized approach by using patient blood-derivable biomaterials as the main construction fabric of wireless medical micromachines to alleviate safety risks from biocompatibility. We demonstrate 3D printed multiresponsive microswimmers and microrollers made from magnetic nanocomposites of blood plasma, serum albumin protein, and platelet lysate. These micro-machines respond to time-variant magnetic fields for torque-driven steerable motion and exhibit multiple cycles of pH-responsive two-way shape memory behavior for controlled cargo delivery and release applications. Their proteinaceous fabrics enable enzymatic degradability with proteinases, thereby lowering risks of long-term toxicity. The personalized micromachine fabrication strategy we conceptualize here can affect various future medical robots and devices made of autologous biomaterials to improve biocompatibility and smart functionality.
引用
收藏
页数:10
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