Evidence of natural Zika virus infection in neotropical non-human primates in Brazil

被引：65

作者：

Terzian, Ana Carolina B. ^{[1
]}

Zini, Nathalia ^{[1
]}

Sacchetto, Livia ^{[2
]}

Rocha, Rebeca Froes ^{[3
]}

Pereira Parra, Maisa Carla ^{[1
]}

Del Sarto, Juliana Lemos ^{[3
]}

Fialho Dias, Ana Carolina ^{[3
]}

Coutinho, Felipe ^{[3
]}

Rayra, Jessica ^{[3
]}

da Silva, Rafael Alves ^{[1
]}

Costa, Vivian Vasconcelos ^{[3
]}

Couto De Azevedo Fernandes, Natalia Coelho ^{[4
]}

Ressio, Rodrigo ^{[4
]}

Diaz-Delgado, Josue ^{[4
]}

Guerra, Juliana ^{[4
]}

Cunha, Mariana S. ^{[4
]}

Catao-Dias, Jose Luiz ^{[5
]}

Bittar, Cintia ^{[6
]}

Negri Reis, Andreia Francesli ^{[7
]}

Penha dos Santos, Izalco Nuremberg ^{[7
]}

Marascalchi Ferreira, Andreia Cristina ^{[7
]}

Arao Antonio Cruz, Lilian Elisa ^{[7
]}

Rahal, Paula ^{[6
]}

Ullmann, Leila ^{[8
]}

Malossi, Camila ^{[8
]}

de Araujo, Joao Pessoa, Jr. ^{[8
]}

Widen, Steven ^{[9
]}

de Rezende, Izabela Mauricio ^{[2
]}

Mello, Erica ^{[10
]}

Pacca, Carolina Colombelli ^{[11
]}

Kroon, Erna Geessien ^{[2
]}

Trindade, Giliane ^{[2
]}

Drumond, Betania ^{[2
]}

Chiaravalloti-Neto, Francisco ^{[12
]}

Vasilakis, Nikos ^{[13
,14
]}

Teixeira, Mauro M. ^{[3
]}

Nogueira, Mauricio Lacerda ^{[1
]}

机构：

[1] Sao Jose do Rio Preto Sch Med FAMERP, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil

[2] Univ Fed Minas Gerais, Lab Virus, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Ctr Drug Res & Dev, Inst Ciencias Biol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[4] IAL, Ave Dr Arnaldo,351-7 Andar,Sala 706, BR-01246000 Sao Paulo, SP, Brazil

[5] Univ Sao Paulo, FMVZ, LAPOCM, Lab Wildlife Comparat Pathol,Dept Pathol,Sch Vet, Ave Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP, Brazil

[6] Sao Paulo State Univ, Inst Biosci Letters & Exact Sci, Dept Biol, Sao Jose Rio Preto IBILCE,UNESP, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil

[7] Epidemiol Surveillance Dept Sao Jose Do Rio Preto, Ave Romeu Strazzi 199, BR-15084010 Sao Jose Do Rio Preto, SP, Brazil

[8] Sao Paulo State Univ Unesp, Inst Biotechnol, Alameda Tecomarias S-N, BR-18607440 Botucatu, SP, Brazil

[9] Univ Texas Med Branch, Dept Biochem & Mol Biol, 301 Univ Blvd, Galveston, TX 77555 USA

[10] Belo Horizonte Council, Ctr Controle Zoonoses, Rua Edna Quintel 173, BR-31270705 Belo Horizonte, MG, Brazil

[11] Faceres Med Sch, Ave Anisio Haddad 6751, BR-15090305 Sao Jose Do Rio Preto, SP, Brazil

[12] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Ave Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil

[13] Univ Texas Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 USA

[14] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Ctr Trop Dis, Inst Human Infect & Immun, 301 Univ Blvd, Galveston, TX 77555 USA

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

巴西圣保罗研究基金会;

关键词：

YELLOW-FEVER; CALLITHRIX-JACCHUS; MODEL; IDENTIFICATION; TRANSMISSION; CHIKUNGUNYA; EMERGENCE; OUTBREAK;

D O I：

10.1038/s41598-018-34423-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NH P ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.

引用

页数：15

共 64 条

[1] Spatial-Temporal Co-Circulation of Dengue Virus 1, 2, 3, and 4 Associated with Coinfection Cases in a Hyperendemic Area of Brazil: A 4-Week Survey [J].