A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis

被引：71

作者：

Castilla-Ortega, Estela ^{[1
]}

Serrano, Antonia ^{[1
]}

Blanco, Eduardo ^{[2
]}

Araos, Pedro ^{[1
]}

Suarez, Juan ^{[1
]}

Pavon, Francisco J. ^{[1
]}

Rodriguez de Fonseca, Fernando ^{[1
]}

Santin, Luis J. ^{[3
]}

机构：

[1] Univ Malaga, Hosp Reg, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Salud Mental, E-29071 Malaga, Spain

[2] Univ Lleida, Fac Educ Psicol & Treball Social, Dept Pedag & Psicol, Lleida, Spain

[3] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Fac Psicol, Dept Psicobiol & Metodol Ciencias Comportamiento, E-29071 Malaga, Spain

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2016年 / 66卷

关键词：

Cocaine addiction vulnerability; Therapeutic approach; Cognition; Emotion; Habits; Brain functional networks; Hippocampal plasticity; Magnetic resonance imaging; Self-administration; Conditioned place preference; VENTRAL TEGMENTAL AREA; DORSOMEDIAL PREFRONTAL CORTEX; CONTEXT-INDUCED REINSTATEMENT; REGULATED GENE-EXPRESSION; DRUG-SEEKING HABITS; DENTATE GYRUS; BASOLATERAL AMYGDALA; CELL-PROLIFERATION; DORSAL HIPPOCAMPUS; NUCLEUS-ACCUMBENS;

D O I：

10.1016/j.neubiorev.2016.03.030

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound cognitive, emotional and motivational alterations emerge from drug-induced neuroadaptations on a vulnerable brain. Therefore, a 'cocaine addiction brain circuit' has been described to explain this disorder. Studies in both cocaine patients and rodents reveal the hippocampus as a main node in the cocaine addiction circuit. The contribution of the hippocampus to cocaine craving and the associated memories is essential to understand the chronic relapsing nature of addiction, which is the main obstacle for the recovery. Interestingly, the hippocampus holds a particular form of plasticity that is rare in the adult brain: the ability to generate new functional neurons. There is an active scientific debate on the contributions of these new neurons to the addicted brain. This review focuses on the potential role(s) of adult hippocampal neurogenesis (AHN) in cocaine addiction. Although the current evidence primarily originates from animal research, these preclinical studies support AHN as a relevant component for the hippocampal effects of cocaine. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：15 / 32

页数：18

共 199 条

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