Comparative Immunogenicity of BNT162b2 mRNA Vaccine with Natural SARS-CoV-2 Infection

被引：9

作者：

Psichogiou, Mina ^{[1
]}

Karabinis, Andreas ^{[2
]}

Poulakou, Garyphallia ^{[3
]}

Antoniadou, Anastasia ^{[4
]}

Kotanidou, Anastasia ^{[5
]}

Degiannis, Dimitrios ^{[2
]}

Pavlopoulou, Ioanna D. ^{[6
]}

Chaidaroglou, Antigoni ^{[2
]}

Roussos, Sotirios ^{[7
]}

Mastrogianni, Elpida ^{[1
]}

Eliadi, Irene ^{[1
]}

Basoulis, Dimitrios ^{[1
]}

Petsios, Konstantinos ^{[8
]}

Leontis, Konstantinos ^{[3
]}

Kakalou, Eleni ^{[3
]}

Protopapas, Konstantinos ^{[4
]}

Jahaj, Edison ^{[5
]}

Pratikaki, Maria ^{[5
]}

Syrigos, Konstantinos N. ^{[3
]}

Lagiou, Pagona ^{[7
]}

Gogas, Helen ^{[1
]}

Tsiodras, Sotirios ^{[4
]}

Magiorkinis, Gkikas ^{[7
]}

Paraskevis, Dimitrios ^{[7
]}

Sypsa, Vana ^{[7
]}

Hatzakis, Angelos ^{[7
,9
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Internal Med 1, Athens 11527, Greece

[2] Onassis Cardiac Surg Ctr, Athens 17674, Greece

[3] Natl & Kapodistrian Univ Athens, Sch Med, Sotiria Gen Hosp, Dept Internal Med 3, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Sch Med, Dept Internal Med 4, Athens 12462, Greece

[5] Natl & Kapodistrian Univ Athens, Sch Med, Evangelismos Hosp, Dept Crit Care & Pulm Serv 1, Athens 10676, Greece

[6] Natl & Kapodistrian Univ Athens, Fac Nursing, Pediat Res Lab, Athens 11527, Greece

[7] Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens 11527, Greece

[8] Onassis Cardiac Surg Ctr, Clin Res Off, Athens 17674, Greece

[9] Hellen Sci Soc Study AIDS Sexually Transmitted &, Athens 11527, Greece

来源：

VACCINES | 2021年 / 9卷 / 09期

关键词：

COVID-19; BNT162b2; vaccine; health care workers; immune response; anti-RBD;

D O I：

10.3390/vaccines9091017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BNT162b2 has proven to be highly effective, but there is a paucity of data regarding immunogenicity factors and comparison between response to vaccination and natural infection. This study included 871 vaccinated healthcare workers (HCW) and 181 patients with natural infection. Immunogenicity was assessed by measuring anti-SARS-CoV-2 against the RBD domain of the spike protein (anti-RBD). Samples were collected 1-2 weeks after vaccination or 15-59 days post-onset of symptoms. Post-vaccine anti-RBD concentrations were associated with age, gender, vaccination side-effects (VSE) and prior infection (Pr-CoV). Anti-RBD median levels (95%CI) were lower by 2466 (651-5583), 6228 (3254-9203) and 7651 (4479-10,823) AU/mL in 35-44, 45-54, 55-70 yrs, respectively, compared with the 18-34 yrs group. In females, the median levels were higher by 2823 (859-4787), 5024 (3122-6926) in individuals with VSE, and 9971 (5158-14,783) AU/mL in HCWs with Pr-CoV. The ratio of anti-RBD in vaccinated individuals versus those with natural infection varied from 1.0 to 19.4. The high immunogenicity of BNT162b2 is verified, although its sustainability has yet to be elucidated. The use of comparative data from natural infection serological panels, expressing the clinical heterogeneity of natural infection, may facilitate early decisions for candidate vaccines to be evaluated in clinical trials.

引用

页数：13

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