Surface modified halloysite nanotubes with different lumen diameters as drug carriers for cancer therapy

被引：21
|
作者：
Liao, Juan [1 ]
Wang, Dongyue [1 ]
Tang, Aidong [2 ]
Fu, Liangjie [1 ,3 ,4 ]
Ouyang, Jing [1 ,4 ]
Yang, Huaming [1 ,3 ,4 ]
机构：
[1] Cent South Univ, Sch Minerals Proc & Bioengn, Hunan Key Lab Mineral Mat & Applicat, Changsha 410083, Peoples R China
[2] Cent South Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China
[3] China Univ Geosci, Engn Res Ctr Nanogeomat, Minist Educ, Wuhan 430074, Peoples R China
[4] Cent South Univ, Hunan Int Joint Lab Mineral Mat, Changsha 410083, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 74期
基金：
中国国家自然科学基金;
关键词：
CLAY NANOTUBES; DELIVERY; NANOPARTICLES;
D O I：
10.1039/d1cc01879e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Paclitaxel (PTX) is successfully loaded by surface modification of distearoyl phosphoethanolamine (DSPE) on halloysite nanotubes (HNTs) with different inner lumen diameters. Drug loading of DSPE-HNTs-PTX attains 18.44% of DSPE content with a nearly complete release (near 100%) achieved. The anticancer efficacy (cell viability less than 52%) of DSPE-HNTs15-PTX increased and is attributed to the lower interfacial energy both inside and outside the tubes that improves tube loading.
引用
收藏
页码：9470 / 9473
页数：4
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