Powder densification. 2. Viscoelastic material properties in modeling the uniaxial compaction of powders

被引:4
作者
Lum, SK
Hoag, SW
Duncan-Hewitt, WC
机构
[1] Univ Toronto, Fac Pharm, Toronto, ON M5S 2S2, Canada
[2] Univ Maryland, Sch Pharm, Baltimore, MD 21201 USA
[3] Grian Facilitat, Amarillo, TX 79106 USA
基金
英国医学研究理事会;
关键词
D O I
10.1021/js9801079
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A micromechanical model for predicting the densification of particulate matter under hydrostatic loading was developed to account for the time-dependent response of materials to applied loads. Viscoelastic material response used in the analysis was based upon a standard three-parameter rheological model. Compaction data under closed die conditions were collected using an Instron analyzer for different rates of applied load. Densification during the loading phase of PMMA/coMMA powder, a pharmaceutical polymeric coating material, was well predicted by the proposed algorithm, which contrasts with the prediction implied through a static indentation model. Secondary factors which affect compaction such as die-wall friction are also briefly discussed.
引用
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页码:909 / 916
页数:8
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