B cells as target for immunotherapy in rheumatic diseases - current status

被引：14

作者：

Bryl, Ewa ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Pathol & Expt Rheumatol, Ul Debinki 7, PL-80210 Gdansk, Poland

来源：

IMMUNOLOGY LETTERS | 2021年 / 236卷

关键词：

Anti-B cells therapy; RA; SLE; pSS; Autoimmunity; Plasma cells; ANTI-CD20; MONOCLONAL-ANTIBODY; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RITUXIMAB-ASSOCIATED HYPOGAMMAGLOBULINEMIA; PRIMARY SJOGRENS-SYNDROME; TREATMENT GUIDELINES; PLASMA-CELLS; PHASE-I/II; ARTHRITIS; EFFICACY; SAFETY;

D O I：

10.1016/j.imlet.2021.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This mini-review is a short overview of different therapeutical strategies targeting B cells in systemic autoimmune rheumatic diseases, mainly: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and primary Sjogren Syndrome (pSS). Many strategies and their rationale are discussed in this review: B cells' depletion (anti-CD20, anti-CD22), long-lived plasma cells depletion (anti-CD19, anti-CD27, anti-CD38 and anti-CD138), changing activation of B cells (anti-BAFF) and inhibiting proteasomes in plasma cells (bortezomib). The past successful therapies and less successful are shown, and the possible reasons for failures are discussed.

引用

页码：12 / 19

页数：8

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