Gender, genetics, and analgesia: understanding the differences in response to pain relief

被引：52

作者：

Packiasabapathy, Senthil ^{[1
]}

Sadhasivam, Senthilkumar ^{[1
]}

机构：

[1] Indiana Univ Hlth, Riley Hosp Children, Dept Anesthesia, RH 2835,705 Riley Hosp Dr, Indianapolis, IN 46202 USA

来源：

JOURNAL OF PAIN RESEARCH | 2018年 / 11卷

关键词：

pain; analgesia; pain genomics; pharmacogenomics; pharmacokinetics; pharmacodynamics; OPIOID RECEPTOR IMMUNOREACTIVITY; SEX-DIFFERENCES; CONGENITAL INSENSITIVITY; NUCLEOTIDE POLYMORPHISM; EPIDERMAL NECROLYSIS; ESTROGEN MODULATION; MENSTRUAL-CYCLE; SELF-EFFICACY; GROWTH-FACTOR; CANCER PAIN;

D O I：

10.2147/JPR.S94650

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic variations and gender contribute significantly to the large interpatient variations in opioid-related serious adverse effects and differences in pain relief with other analgesics. Opioids are the most commonly used analgesics to relieve moderate-to-severe postoperative pain. Narrow therapeutic index and unexplained large interpatient variations in opioid-related serious adverse effects and analgesia negatively affect optimal perioperative outcomes. In surgical, experimental, chronic, and neuropathic pain models, females have been reported to have more pain than males. This review focuses on literature evidence of differences in pain relief due to multiple genetic variations and gender of the patient.

引用

页码：2729 / 2739

页数：11

共 139 条

[1] Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: A prospective double-blind randomized placebo-controlled study [J].