Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control - A Jordanian Study

被引：10

作者：

Bawadi, Hiba ^{[1
]}

Katkhouda, Rami ^{[2
]}

Tayyem, Reema ^{[3
]}

Kerkadi, Abdelhamid ^{[1
]}

Raad, Samira Bou ^{[4
]}

Subih, Hadil ^{[2
]}

机构：

[1] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Bldg 106,Univ St,POB 2713, Doha, Qatar

[2] Jordan Univ Sci & Technol, Dept Nutr & Food Technol, Irbid, Jordan

[3] Univ Jordan, Dept Clin Nutr & Dietet, Amman, Jordan

[4] Amer Univ Sci & Technol, Dept Nutr & Food Sci, Beirut, Lebanon

来源：

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2019年 / 12卷

关键词：

BMI; C-reactive protein; diabetes; IL-6; inflammation; obesity; C-REACTIVE PROTEIN; OXIDATIVE STRESS; BODY-FAT; INSULIN-RESISTANCE; TNF-ALPHA; MASS; ADIPOSITY; MELLITUS; OBESITY; HYPERGLYCEMIA;

D O I：

10.2147/DMSO.S214426

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aim: Systemic inflammation is related to the progression of complications associated with diabetes. This study aimed to investigate the association between general and abdominal obesity and inflammation in patients with type-2 diabetes with or without glycemic control. Methods: A total of 198 men (n=73) and women (n=125) diagnosed with type 2 diabetes participated in this study. General obesity markers, body mass index (BMI), and abdominal fat were assessed. Circulating concentrations of glycated hemoglobin (HbA1C), C-reactive protein (CRP), and serum interleukin-6 (IL-6) were determined. Poor glycemic control and good glycemic control were defined as having fasting HbA1C concentrations >= 7% and <7%, respectively. Multivariate adjusted analysis of covariance was used to determine the relation between BMI and abdominal fat and markers of inflammation in patients with good and poor glycemic control. Results: Patients in <7% HbA1C category, those with high abdominal fat had approximate to 262% higher CRP and approximate to 30.6% higher IL-6 compared to those with low abdominal fat (p<0.05). Patients in >= 7% HbA1C category, those with high abdominal fat had approximate to 41.4% higher CRP and approximate to 33.9% higher IL-6 compared to those with low abdominal fat (p<0.05). Abdominal fat was directly related to CRP (p<0.023) and IL-6 (p<0.002) concentrations in both groups of type-2 diabetic patients with <7% and >= 7% HbA1C. In patients with >= 7% HbA1C, BMI was directly related to CRP (p<0.02) and IL-6 (p<0.047). Whereas in patients with <7% HbA1C, BMI was not associated with CRP or IL-6 concentrations. Conclusion: High level of abdominal fat is associated with systemic inflammation in type-2 diabetes regardless of glycemic control. Abdominal fat is a better predictor (determinant) of inflammation than BMI in patients with type-2 diabetes with or without glycemic control.

引用

页码：2411 / 2417

页数：7

共 45 条

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