Synthesis, characterization, anticancer activity, and molecular docking of some new sugar hydrazone and arylidene derivatives

被引：16

作者：

Alotabi, Saad H. ^{[1
]}

机构：

[1] Taif Univ, Turabah Univ Coll, Dept Chem, Box 311, At Taif 21995, Saudi Arabia

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2020年 / 13卷 / 03期

关键词：

Sugar hydrazones; Arylidene derivatives; Oxadiazolines; Molecular docking; Antimicrobial activity; DRUG DISCOVERY; PREDICTION;

D O I：

10.1016/j.arabjc.2019.12.006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New sugar hydrazone moieties, their oxadiazoline derivatives, and arylidene analogues were prepared and chemically elucidated using spectroscopic analysis, such as nuclear magnetic resonance, for hydrogen (HNMR)-H-1, carbon (CNMR)-C-13, elemental analysis, and Infrared (IR). The prepared compounds were purified and tested against breast cancer cells (MCF-7). Compounds 4c, 4d, 6b, and 6d exhibited moderate to very high anti-breast cancer activity, with a percentage of inhibition of 96.19%, 93.08%, 74.33%, and 86.05% respectively; the reference 5-fluorouracil had an inhibitory percentage of 96.02%. (C) 2020 The Author. Published by Elsevier B.V. on behalf of King Saud University.

引用

页码：4771 / 4784

页数：14

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