mTORC1 and IRS1: Another Deadly Kiss

被引：15

作者：

Ardestani, Amin ^{[1
]}

Maedler, Kathrin ^{[1
]}

机构：

[1] Univ Bremen, Ctr Biomol Interact Bremen, D-28359 Bremen, Germany

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 11期

关键词：

METABOLISM;

D O I：

10.1016/j.tem.2018.07.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mechanistic target of rapamycin complex (mTORC) 1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic demand. In their recent study, Yoneyama et al. have identified and characterized a negative feedback loop from mTORC1 to insulin receptor substrate (IRS) 1; the key component of the insulin/insulin-like growth factor (IGF) signaling pathway.

引用

页码：737 / 739

页数：3

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