HIV-1, human interaction database: current status and new features

被引：71

作者：

Ako-Adjei, Danso ^{[1
]}

Fu, William ^{[2
]}

Wallin, Craig ^{[1
]}

Katz, Kenneth S. ^{[1
]}

Song, Guangfeng ^{[1
]}

Darji, Dakshesh ^{[1
]}

Brister, J. Rodney ^{[1
]}

Ptak, Roger G. ^{[2
]}

Pruitt, Kim D. ^{[1
]}

机构：

[1] Natl Lib Med, Natl Inst Biotechnol Informat, NIH, Bethesda, MD 20894 USA

[2] So Res Inst, Dept Infect Dis Res, Frederick, MD 21701 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; NONCODING RNAS; EXPRESSION; CHROMATIN; NETWORKS; PATHWAYS; REVEALS; RISK; AIDS;

D O I：

10.1093/nar/gku1126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 'Human Immunodeficiency Virus Type 1 (HIV-1), Human Interaction Database', available through the National Library of Medicine at http://www.ncbi.nlm.nih.gov/genome/viruses/retroviruses/hiv-1/interactions, serves the scientific community exploring the discovery of novel HIV vaccine candidates and therapeutic targets. Each HIV-1 human protein interaction can be retrieved without restriction by web-based downloads and ftp protocols and includes: Reference Sequence (RefSeq) protein accession numbers, National Center for Biotechnology Information Gene identification numbers, brief descriptions of the interactions, searchable keywords for interactions and PubMed identification numbers (PMIDs) of journal articles describing the interactions. In addition to specific HIV-1 protein-human protein interactions, included are interaction effects upon HIV-1 replication resulting when individual human gene expression is blocked using siRNA. A total of 3142 human genes are described participating in 12 786 protein-protein interactions, along with 1316 replication interactions described for each of 1250 human genes identified using small interfering RNA (siRNA). Together the data identifies 4006 human genes involved in 14 102 interactions. With the inclusion of siRNA interactions we introduce a redesigned web interface to enhance viewing, filtering and downloading of the combined data set.

引用

页码：D566 / D570

页数：5

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