The evolving role of lymphatics in cancer metastasis

被引：72

作者：

Farnsworth, Rae H. ^{[1
,2
]}

Achen, Marc G. ^{[1
,2
]}

Stacker, Steven A. ^{[1
,2
]}

机构：

[1] Peter MacCallum Canc Ctr, Tumour Angiogenesis & Microenvironm Program, 305 Grattan St, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2018年 / 53卷

基金：

英国医学研究理事会;

关键词：

ENDOTHELIAL-CELLS; T-CELL; BLOOD-VESSELS; NODE; LYMPHANGIOGENESIS; GROWTH; VASCULATURE; DISSECTION; EXPRESSION; IMMUNITY;

D O I：

10.1016/j.coi.2018.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying mechanisms is still evolving. Lymphatic vessels provide a route for tumour cells to reach regional lymph nodes (LNs), which is prognostic of distant organ metastasis and poor survival. However, genomic analyses of metastatic cancer now reveal complex patterns of dissemination. The lymphatic endothelial cells lining lymphatics respond to molecular cues from the tumour microenvironment, mediating growth and remodelling of lymphatic vessels at the primary tumour, draining LNs and distant premetastatic niches. Recent studies emphasise that this not only supports metastasis but also influences antitumour immunity. Understanding the complex interactions between tumour cells, the immune system and lymphatics will be essential to inform developing therapeutic and prognostic approaches to cancer.

引用

页码：64 / 73

页数：10

共 65 条

[1] Development and plasticity of meningeal lymphatic vessels [J].

Antila, Salli ;

Karaman, Sinem ;

Nurmi, Harri ;

Airavaara, Mikko ;

Voutilainen, Merja H. ;

Mathivet, Thomas ;

Chilov, Dmitri ;

Li, Zhilin ;

Koppinen, Tapani ;

Park, Jun-Hee ;

Fang, Shentong ;

Aspelund, Aleksanteri ;

Saarma, Mart ;

Eichmann, Anne ;

Thomas, Jean-Leon ;

Alitalo, Kari .

JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (12) :3645-3667

[2] A specific immune and lymphatic profile characterizes the pre-metastatic state of the sentinel lymph node in patients with early cervical cancer [J].

Balsat, Cedric ;

Blacher, Silvia ;

Herfs, Michael ;

Van de Velde, Maureen ;

Signolle, Nicolas ;

Sauthier, Philippe ;

Pottier, Charles ;

Gofflot, Stephanie ;

De Cuypere, Marjolein ;

Delvenne, Philippe ;

Goffin, Frederic ;

Noel, Agnes ;

Kridelka, Frederic .

ONCOIMMUNOLOGY, 2017, 6 (02)

[3] Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis [J].

Becker, Annette ;

Thakur, Basant Kumar ;

Weiss, Joshua Mitchell ;

Kim, Han Sang ;

Peinado, Hector ;

Lyden, David .

CANCER CELL, 2016, 30 (06) :836-848

[4] Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice [J].

Brown, M. ;

Assen, F. P. ;

Leithner, A. ;

Abe, J. ;

Schachner, H. ;

Asfour, G. ;

Bago-Horvath, Z. ;

Stein, J. V. ;

Uhrin, P. ;

Sixt, M. ;

Kerjaschki, D. .

SCIENCE, 2018, 359 (6382) :1408-+

[5]

Brunocilla E, 2011, ANTICANCER RES, V31, P271

[6]

Carriere V, 2008, CANCER RES, P14

[7] A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis [J].

Clasper, Steven ;

Royston, Daniel ;

Baban, Dilair ;

Cao, Yihai ;

Ewers, Stephan ;

Butz, Stefan ;

Vestweber, Dietmar ;

Jackson, David G. .

CANCER RESEARCH, 2008, 68 (18) :7293-7303

[8] Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses [J].

Das, Suvendu ;

Sarrou, Eliana ;

Podgrabinska, Simona ;

Cassella, Melanie ;

Mungamuri, Sathish Kumar ;

Feirt, Nikki ;

Gordon, Ronald ;

Nagi, Chandandeep S. ;

Wang, Yarong ;

Entenberg, David ;

Condeelis, John ;

Skobe, Mihaela .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (08) :1509-1528

[9] Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation [J].

Dieterich, Lothar C. ;

Ikenberg, Kristian ;

Cetintas, Timur ;

Kapaklikaya, Kuebra ;

Hutmacher, Cornelia ;

Detmar, Michael .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[10] Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma [J].

Fankhauser, Manuel ;

Broggi, Maria A. S. ;

Potin, Lambert ;

Bordry, Natacha ;

Jeanbart, Laura ;

Lund, Amanda W. ;

Da Costa, Elodie ;

Hauert, Sylvie ;

Rincon-Restrepo, Marcela ;

Tremblay, Christopher ;

Cabello, Elena ;

Homicsko, Krisztian ;

Michielin, Olivier ;

Hanahan, Douglas ;

Speiser, Daniel E. ;

Swartz, Melody A. .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (407)

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