Importance of biologic parameters in Helicobacter pylori gastritis: comparison with histological results

被引：0

作者：

Abaza, Hajer ^{[1
]}

Ghanem, Abderraouf ^{[1
]}

Karoui, Jeannette ^{[1
]}

Jmal, Aouatef ^{[1
]}

Dhouib, Rabiaa ^{[2
]}

Harzallah, Latifa ^{[1
]}

Ben Mami, Nabyl ^{[2
]}

Khaled, Rahal ^{[3
]}

Guemira, Fethi ^{[1
]}

机构：

[1] Inst Salah Azaiz, Serv Biol Clin, Tunis, Tunisia

[2] Inst Salah Azaiz, Serv Gastroentrol, Tunis, Tunisia

[3] Inst Salah Azaiz, Serv Chirurg Carcinol, Tunis, Tunisia

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2010年 / 68卷 / 04期

关键词：

gastritis; Helicobacter pylori; gastrin; 17; pepsinogen; 1; 2; histology; ATROPHIC GASTRITIS; SERUM PEPSINOGEN; DYSPEPTIC PATIENTS; PRIMARY-CARE; GASTRIN-17; ANTIBODIES; DIAGNOSIS; CANCER; BIOMARKERS; MANAGEMENT;

D O I：

10.1684/abc.2010.0460

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Helicobacter pylori (HP) chronic gastritis can lead to precursor stages of gastric cancer. New biological markers have been proposed to study the gastric mucosal state. We evaluate biological results in comparison with histological ones in a dyspeptic population. Forty nine dyspeptic patients underwent endoscopy with gastric biopsies for histological examination. Blood samples were obtained to measure levels of gastrin 17 (G17), pepsinogen 1 (PG1), pepsinogen 2 (PG2) and the rate of anti-HP IgG antibodies. Four patients have a healthy gastric mucosa and 45 have a gastritis (32 have a nonatrophic gastritis and 13 an atrophic one). An increase in the level of PG2 and a decrease of the PG1/PG2 ratio were noticed in the group of subjects with a nonatrophic gastritis compared to the healthy mucosa group. The decrease of the PG1/PG2 ratio was more important in the corpus atrophic gastritis group than in the antrum restricted atrophic gastritis one. In conclusion, in front of dyspeptic patients, we advice to practice in first intention the measurement of the serological level of G17, PG1, PG2 and anti-HP IgG antibodies.

引用

页码：473 / 479

页数：7

共 21 条

[1] Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy [J].