Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

被引：2840

作者：

Druker, BJ ^{[1
]}

Tamura, S ^{[1
]}

Buchdunger, E ^{[1
]}

Ohno, S ^{[1
]}

Segal, GM ^{[1
]}

Fanning, S ^{[1
]}

Zimmermann, J ^{[1
]}

Lydon, NB ^{[1
]}

机构：

[1] CIBA GEIGY AG, ONCOL RES DEPT, CIBA PHARMACEUT DIV, CH-4002 BASEL, SWITZERLAND

来源：

NATURE MEDICINE | 1996年 / 2卷 / 05期

关键词：

D O I：

10.1038/nm0596-561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bcr-abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of this disease. A compound, designed to inhibit the Abl protein tyrosine kinase, was evaluated for its effects on cells containing the Bcr-Abl fusion protein. Cellular proliferation and tumor formation by Bcr-Abl-expressing cells were specifically inhibited by this compound. In colony-forming assays of peripheral blood or bone marrow from patients with CML, there was a 92-98% decrease in the number of bcr-abl colonies formed but no inhibition of normal colony formation. This compound may be useful in the treatment of bcr-abl-positive leukemias.

引用

页码：561 / 566

页数：6

共 52 条

[1]

ALLAN NC, 1994, BLOOD, V84, pA382

[2]

ANAFI M, 1993, BLOOD, V82, P3524

[3] CDC2 IS A COMPONENT OF THE M-PHASE SPECIFIC HISTONE-H1 KINASE - EVIDENCE FOR IDENTITY WITH MPF [J].

ARION, D ;

MEIJER, L ;

BRIZUELA, L ;

BEACH, D .

CELL, 1988, 55 (02) :371-378

[4] SELECTIVE GROWTH-RESPONSE TO IL-3 OF A HUMAN-LEUKEMIC CELL-LINE WITH MEGAKARYOBLASTIC FEATURES [J].

AVANZI, GC ;

LISTA, P ;

GIOVINAZZO, B ;

MINIERO, R ;

SAGLIO, G ;

BENETTON, G ;

CODA, R ;

CATTORETTI, G ;

PEGORARO, L .

BRITISH JOURNAL OF HAEMATOLOGY, 1988, 69 (03) :359-366

[5] TRANSLOCATION OF C-ABL ONCOGENE CORRELATES WITH THE PRESENCE OF A PHILADELPHIA-CHROMOSOME IN CHRONIC MYELOCYTIC-LEUKEMIA [J].

BARTRAM, CR ;

DEKLEIN, A ;

HAGEMEIJER, A ;

VANAGTHOVEN, T ;

VANKESSEL, AG ;

BOOTSMA, D ;

GROSVELD, G ;

FERGUSONSMITH, MA ;

DAVIES, T ;

STONE, M ;

HEISTERKAMP, N ;

STEPHENSON, JR ;

GROFFEN, J .

NATURE, 1983, 306 (5940) :277-280

[6]

BEDI A, 1994, BLOOD, V83, P2038

[7] 4,5-DIANILINOPHTHALIMIDE - A PROTEIN-TYROSINE KINASE INHIBITOR WITH SELECTIVITY FOR THE EPIDERMAL GROWTH-FACTOR RECEPTOR SIGNAL-TRANSDUCTION PATHWAY AND POTENT IN-VIVO ANTITUMOR-ACTIVITY [J].

BUCHDUNGER, E ;

TRINKS, U ;

METT, H ;

REGENASS, U ;

MULLER, M ;

MEYER, T ;

MCGLYNN, E ;

PINNA, LA ;

TRAXLER, P ;

LYDON, NB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2334-2338

[8] SELECTIVE-INHIBITION OF THE PLATELET-DERIVED GROWTH-FACTOR SIGNAL-TRANSDUCTION PATHWAY BY A PROTEIN-TYROSINE KINASE INHIBITOR OF THE 2-PHENYLAMINOPYRIMIDINE CLASS [J].

BUCHDUNGER, E ;

ZIMMERMANN, J ;

METT, H ;

MEYER, T ;

MULLER, M ;

REGENASS, U ;

LYDON, NB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2558-2562

[9] LINEAGE-SPECIFIC REQUIREMENT OF C-ABL FUNCTION IN NORMAL HEMATOPOIESIS [J].

CARACCIOLO, D ;

VALTIERI, M ;

VENTURELLI, D ;

PESCHLE, C ;

GEWIRTZ, AM ;

CALABRETTA, B .

SCIENCE, 1989, 245 (4922) :1107-1110

[10] EXPRESSION OF A DISTINCTIVE BCR-ABL ONCOGENE IN PH1-POSITIVE ACUTE LYMPHOCYTIC-LEUKEMIA (ALL) [J].

CLARK, SS ;

MCLAUGHLIN, J ;

TIMMONS, M ;

PENDERGAST, AM ;

BEN-NERIAH, Y ;

DOW, LW ;

CRIST, W ;

ROVERA, G ;

SMITH, SD ;

WITTE, ON .

SCIENCE, 1988, 239 (4841) :775-777

← 1 2 3 4 5 6 →