Platelet-rich plasma plus β-tricalcium-phosphate -: A new strategy of bone grafting

In case of large posttraumatic or tumor-induced bone-defects substitution of bone in human as well as in veterinary medicine is still a problem to solve. Ceramics and bio-glasses developed in the past have been proved as fill-ins with only minor osteoconductive abilities. Autologous cancellous bone as "golden standard" in bone grafting could not be replaced. With introduction of a composite-transplant consisting of osteoconductive acting beta -Tricalciumphophate and osteoinductive growth factors such as platelet-derived growth factor, transforming growth factor-beta 1 and 2 and insulin-like growth factor-I taken from platelet-rich plasma a new strategy of bone grafting is presented which should be able to answer many of the questions connected with reconstructive bone grafting today.