The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

被引：9
|
作者：
Nonogaki, Katsunori [1 ]
Kaji, Takao [1 ]
机构：
[1] Tohoku Univ, Grad Sch Biomed Engn, Dept Diabet Technol, Sendai, Miyagi, Japan
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2016年 / 120卷
关键词：
Liraglutide; GLP-1; receptor; POMC; Orexin; 5-HT; Food intake; ARCUATE NUCLEUS; OBESITY; OREXIN; 5-HT2C;
D O I：
10.1016/j.diabres.2016.08.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：186 / 189
页数：4
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