The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

被引：9
|
作者：
Nonogaki, Katsunori [1 ]
Kaji, Takao [1 ]
机构：
[1] Tohoku Univ, Grad Sch Biomed Engn, Dept Diabet Technol, Sendai, Miyagi, Japan
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2016年 / 120卷
关键词：
Liraglutide; GLP-1; receptor; POMC; Orexin; 5-HT; Food intake; ARCUATE NUCLEUS; OBESITY; OREXIN; 5-HT2C;
D O I：
10.1016/j.diabres.2016.08.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, did not require functional leptin receptor, serotonin, and hypothalamic proopiomelanocortin and cocaine amphetamine regulated transcript activities in mice, although decrease in functional hypothalamic orexin activity might be involved in the acute anorexic effect of liraglutide. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：186 / 189
页数：4
相关论文
共 30 条
  • [1] The GLP-1 Receptor Agonist Liraglutide Decreases Primary Bile Acids and Serotonin in the Colon Independently of Feeding in Mice
    Nonogaki, Katsunori
    Kaji, Takao
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (14)
  • [2] Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice
    Nonogaki, Katsunori
    Kaji, Takao
    JOURNAL OF DIABETES RESEARCH, 2018, 2018
  • [3] Effect of GLP-1 receptor agonist, liraglutide, on muscle in spontaneously diabetic torii fatty rats
    Yamada, Shohei
    Ogura, Yuji
    Inoue, Kazuho
    Tanabe, Jun
    Sugaya, Takeshi
    Ohata, Keiichi
    Nagai, Yoshio
    Natsuki, Yasunori
    Hoshino, Seiko
    Watanabe, Shiika
    Ichikawa, Daisuke
    Kimura, Kenjiro
    Shibagaki, Yugo
    Kamijo-Ikemori, Atsuko
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2022, 539
  • [4] GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome
    Kadri Seppa
    Maarja Toots
    Riin Reimets
    Toomas Jagomäe
    Tuuliki Koppel
    Maia Pallase
    Stine Hasselholt
    Maiken Krogsbæk Mikkelsen
    Jens Randel Nyengaard
    Eero Vasar
    Anton Terasmaa
    Mario Plaas
    Scientific Reports, 9
  • [5] GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome
    Seppa, Kadri
    Toots, Maarja
    Reimets, Riin
    Jagomae, Toomas
    Koppel, Tuuliki
    Pallase, Maia
    Hasselholt, Stine
    Mikkelsen, Maiken Krogsbaek
    Nyengaard, Jens Randel
    Vasar, Eero
    Terasmaa, Anton
    Plaas, Mario
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [6] Effect of the GLP-1 Receptor Agonist, Liraglutide as an Adjunct to Insulin Treatment in a Rodent Model of Type 1 Diabetes
    Meek, Thomas H.
    Kumar, Monica
    Matsen, Miles E.
    Fischer, Jonathan D.
    Taborsky, Gerald J., Jr.
    Schwartz, Michael W.
    Morton, Gregory J.
    DIABETES, 2013, 62 : A733 - A733
  • [7] GLP-1 receptor agonist, liraglutide, ameliorates hepatosteatosis induced by anti-CD3 antibody in female mice
    Itoh, Arata
    Irie, Junichiro
    Tagawa, Hirotsune
    Kusumoto, Yukie
    Kato, Mari
    Kobayashi, Nana
    Tanaka, Kumiko
    Kikuchi, Rieko
    Fujita, Masataka
    Nakajima, Yuya
    Wu, Yuehong
    Yamada, Satoru
    Kawai, Toshihide
    Ridgway, William M.
    Itoh, Hiroshi
    JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, 31 (09) : 1370 - 1375
  • [8] Delayed administration of the GLP-1 receptor agonist liraglutide improves metabolic and functional recovery after cerebral ischemia in rats
    Dong, Wenbin
    Miao, Yunping
    Chen, Aiying
    Cheng, Min
    Ye, Xiaodi
    Song, Fahuan
    Zheng, Gaoli
    NEUROSCIENCE LETTERS, 2017, 641 : 1 - 7
  • [9] Cotadutide (GLP-1/Glucagon dual receptor agonist) modulates hypothalamic orexigenic and anorexigenic neuropeptides in obese mice
    Spezani, Renata
    Marinho, Thatiany Souza
    Reis, Thiago Santos
    Aguila, Marcia Barbosa
    Mandarim-de-Lacerda, Carlos A.
    PEPTIDES, 2024, 173
  • [10] GLP-1 receptor agonist liraglutide exerts central action to induce β-cell proliferation through medulla to vagal pathway in mice
    Kumari, Parmila
    Nakata, Masanori
    Zhang, Bo Yang
    Otgon-Uul, Zesemdorj
    Yada, Toshihiko
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 499 (03) : 618 - 625
123